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Titolo:
Effects of cholinergic agents on the vasopressin-mediated water transport in the isolated toad bladder
Autore:
Leite, RS; Franco, W;
Indirizzi:
UFSCar, DCF, Dept Physiol Sci, BR-13565905 Sao Carlos, SP, Brazil UFSCar Sao Carlos SP Brazil BR-13565905 BC13565905 Sao Carlos, SP, Brazil
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
fascicolo: 2, volume: 129, anno: 2001,
pagine: 129 - 136
SICI:
1532-0456(200106)129:2<129:EOCAOT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
URINARY-BLADDER; ANTIDIURETIC-HORMONE; CYCLIC-AMP; CALCIUM; RECEPTORS; ACETYLCHOLINE; INNERVATION; STIMULATION; CALMODULIN; KIDNEY;
Keywords:
toad urinary bladder; muscarinic receptors; arginine vasopressin; 3 ' 5 ' cAMP; carbachol; lanthanum; atropine; pirenzepine; 4-DAMP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Franco, W UFSCar, DCF, Dept Physiol Sci, CP 676, BR-13565905 Sao Carlos, SP, Brazil UFSCar CP 676 Sao Carlos SP Brazil BR-13565905 BClos, SP, Brazil
Citazione:
R.S. Leite e W. Franco, "Effects of cholinergic agents on the vasopressin-mediated water transport in the isolated toad bladder", COMP BIOC C, 129(2), 2001, pp. 129-136

Abstract

The aim of this work was to study the effect of some pharmacological cholinergic agents on the events that follow the interaction of arginine vasopressin with toad bladder membrane receptors related to synthesis of 3 '5 ' (c)AMP. The water Bow through the membrane was measured gravimetrically in sac preparations of the membrane. In the absence of arginine vasopressin (AVP), carbachol induced a significant increase in the water flow (37%) relatedto the basal (Ringer's solution). On the other hand, when carbachol and AVP were associated, a significant decrease of AVP hydrosmotic activity occurred (23%). The inhibitory effect of carbachol on the AVP action was almost completely abolished by the cholinergic antagonists atropine, pirenzepine, 4-diphenylacetoxy-N-methylpiperidine methiodide (4-DAMP) and the calcium antagonist lanthanum. Similarly, when carbachol and 3 '5 ' cyclic adenosine monophosphate (3 '5 ' (c)AMP) were associated, a decrease of nucleotide hydrosmotic activity was observed (12.80%). This effect was partially restored by the addition of pirenzepine or 4-DAMP in the bath solution. These results suggest a role for muscarinic receptors of sub-type M-1 and M-3, which are involved in the intracellular calcium release. The increase of calcium concentration in the intracellular medium acts as a negative modulator in thehydrosmotic action of antidiuretic hormone. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 10:37:10