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Titolo:
Complement-regulator factor H and related proteins in otitis media with effusion
Autore:
Narkio-Makela, M; Hellwage, J; Tahkokallio, O; Meri, S;
Indirizzi:
Univ Helsinki, Dept Bacteriol & Immunol, Haartman Inst, Helsinki, Finland Univ Helsinki Helsinki Finland mmunol, Haartman Inst, Helsinki, Finland Jorvi Hosp, Dept Otorhinolaryngol Head & Neck Surg, SF-02740 Espoo, Finland Jorvi Hosp Espoo Finland SF-02740 d & Neck Surg, SF-02740 Espoo, Finland Hans Knoell Inst Nat Prod Res, Mol Immunobiol Grp, D-07745 Jena, Germany Hans Knoell Inst Nat Prod Res Jena Germany D-07745 D-07745 Jena, Germany Univ Helsinki, Cent Hosp, Dept Otorhinolaryngol Head & Neck Surg, Helsinki, Finland Univ Helsinki Helsinki Finland ngol Head & Neck Surg, Helsinki, Finland
Titolo Testata:
CLINICAL IMMUNOLOGY
fascicolo: 1, volume: 100, anno: 2001,
pagine: 118 - 126
SICI:
1521-6616(200107)100:1<118:CFHARP>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALTERNATIVE PATHWAY; HEPARIN-BINDING; MIDDLE-EAR; EXPRESSION; CHILDREN; FHR-4; C3D;
Keywords:
complement activation; otitis media with effusion; OME; factor H; FHL-1; FHR-1; FHR-2; FHR-3; FHR-4; FHR-5;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Narkio-Makela, M Univ Helsinki, Dept Bacteriol & Immunol, Haartman Inst, Haartmaninkatu 3, Helsinki, Finland Univ Helsinki Haartmaninkatu 3 HelsinkiFinland Finland
Citazione:
M. Narkio-Makela et al., "Complement-regulator factor H and related proteins in otitis media with effusion", CLIN IMMUNO, 100(1), 2001, pp. 118-126

Abstract

Otitis media with effusion (OME) is a common disease in childhood. It is characterized by chronic inflammation in which the proinflammatory activity of the complement (C) system is one of the underlying factors. The C systembecomes strongly activated in the middle ear effusion (MEE) fluid, but thereasons for this are not known. Here we demonstrate by using complement Bbfragment ELISA that MEE specimens strongly activate the alternative C pathway (AP) in normal human serum (NHS). Some of the MEEs were also found to promote lysis of rabbit erythrocytes by NHS. These findings indicated a disturbance in the fluid-phase regulation of the AP in MEE. The main regulator of the AP, factor H (FH), and proteins structurally related to it (FHL-1, FHR-1, -2, -3, and -4) were present in the MEE fluids of OME patients. Relative to serum, the FHR proteins were more abundant in the MEEs. In addition,we detected the recently discovered 65-kDa FH-related protein FHR-5 in theMEE. The FHR proteins share binding sites with FH in the C3d region of C3b. Thus they may compete with FH in binding to C3b and interfere with the regulatory activity of FH. Consequently, a disturbance in AP control in the MEE may lead to an ongoing excessive C activation and inflammation in OME. (C) 2001 Academic Press.

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Documento generato il 28/02/20 alle ore 23:04:16