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Titolo:
Increased CCR5 and CXCR4 expression in Ethiopians living in Israel: Environmental and constitutive factors
Autore:
Kalinkovich, A; Borkow, G; Weisman, Z; Tsimanis, A; Stein, M; Bentwich, Z;
Indirizzi:
Hebrew Univ Jerusalem, Hadassah Med Sch, Kaplan Med Ctr, R Ben Ari Inst Clin Immunol & AIDS Ctr, IL-76100 Rehovot, Israel Hebrew Univ Jerusalem Rehovot Israel IL-76100 , IL-76100 Rehovot, Israel
Titolo Testata:
CLINICAL IMMUNOLOGY
fascicolo: 1, volume: 100, anno: 2001,
pagine: 107 - 117
SICI:
1521-6616(200107)100:1<107:ICACEI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS TYPE-1; CD4(+) T-CELLS; CHEMOKINE RECEPTOR EXPRESSION; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; MONOCYTE-DERIVED MACROPHAGES; INHIBITS HIV-1 REPLICATION; BLOOD MONONUCLEAR-CELLS; IMMUNE ACTIVATION; IN-VITRO; TNF-ALPHA;
Keywords:
CCR5; CXCD4; Ethiopians; immune activation; susceptibility for HIV infection; Africa;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Bentwich, Z Hebrew Univ Jerusalem, Hadassah Med Sch, Kaplan Med Ctr, R BenAri Inst Clin Immunol & AIDS Ctr, IL-76100 Rehovot, Israel Hebrew Univ Jerusalem Rehovot Israel IL-76100 ehovot, Israel
Citazione:
A. Kalinkovich et al., "Increased CCR5 and CXCR4 expression in Ethiopians living in Israel: Environmental and constitutive factors", CLIN IMMUNO, 100(1), 2001, pp. 107-117

Abstract

HIV coreceptors play a major role in determining susceptibility and HIV cell tropism. The present work studied whether the high expression of these coreceptors found on lymphocytes and monocytes of Ethiopian immigrants to Israel (ETH) is the result of environmental and/or constitutive genetic factors. The study of 26 ETH shortly after their arrival to Israel (new ETH), 22ETH in Israel over 7 years told ETH), and 20 Caucasian Israelis (non-ETH) enabled us to address this issue. The new ETH had elevated levels of activated HLA-DR(+)CD4(+) and CD38(+)CD8(+) cells in comparison with both old ETHand non-ETH groups (P < 0.01), most probably related to chronic helminthicinfections. Surface CCR5 expression, i.e., the percentage of CCR5(+) cellsand the number of CCR5 molecules/cell, was higher (2- to 3- and 8- to 31-fold, respectively) in activated than in nonactivated CD4(+) cells, in all groups. However, CCR5 expression, in both activated and nonactivated CD4(+) cells, was higher in both ETH groups than in the non-ETH group. CXCR4 expression was higher in nonactivated CD4(+) cells in all groups and was also higher in both ETH groups, in both activated and nonactivated CD4(+) cells, than in the non-ETH group. These findings suggest that constitutive factors,in addition to immune activation caused by environmental factors, account for the elevated expression of CCR5 and CXCR4 on CD4(+) cells of ETH. This increased HIV coreceptor expression may make ETH more susceptible to HIV infection and may account in part for the rapid spread of AIDS in Ethiopia and the rest of Africa as well. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 12:05:08