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Titolo:
Activation of peripheral blood neutrophils from patients with active advanced tuberculosis
Autore:
Aleman, M; Beigier-Bompadre, M; Borghetti, C; de la Barrera, S; Abbate, E; Isturiz, M; Sasiain, MD;
Indirizzi:
Acad Nacl Med, Inst Invest Hematol, Dept Inmunol, Buenos Aires, DF, Argentina Acad Nacl Med Buenos Aires DF Argentina nol, Buenos Aires, DF, Argentina Hosp F J Muniz, Div Tisioneumonol, Buenos Aires, DF, Argentina Hosp F J Muniz Buenos Aires DF Argentina ol, Buenos Aires, DF, Argentina
Titolo Testata:
CLINICAL IMMUNOLOGY
fascicolo: 1, volume: 100, anno: 2001,
pagine: 87 - 95
SICI:
1521-6616(200107)100:1<87:AOPBNF>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; COLONY-STIMULATING FACTOR; MYCOBACTERIUM-TUBERCULOSIS; RESPIRATORY BURST; FC-RECEPTORS; FACTOR-ALPHA; POLYMORPHONUCLEAR NEUTROPHILS; PULMONARY TUBERCULOSIS; IMMUNE-COMPLEXES; GENE-EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Aleman, M Acad Nacl Med, Inst Invest Hematol, Dept Inmunol, Buenos Aires, DF, Argentina Acad Nacl Med Buenos Aires DF Argentina s Aires, DF, Argentina
Citazione:
M. Aleman et al., "Activation of peripheral blood neutrophils from patients with active advanced tuberculosis", CLIN IMMUNO, 100(1), 2001, pp. 87-95

Abstract

Activation of peripheral blood neutrophils (PMN) was investigated in orderto determine whether they might contribute to the inflammatory process during active advanced tuberculosis. Receptors for the Fc portion of IgG (Fc gammaR) (Fc gamma RI, Fc gamma RII, and Fc gamma RIIIB), CD66 (degranulationmarker), and receptors for tumor necrosis factor-alpha (TNF-R55 and TNF-R75) were analyzed on PMN obtained from normal controls and tuberculosis patients (TB-PMN). Functional parameters such as cytotoxicity, superoxide aniongeneration triggered by N-formyl-methionyl-leucyl-phenyl-alanine (FMLP), and TNF-alpha and IL-1 beta production were evaluated, A high expression of TNF-R55, CD66, and Fc gamma RIIIB and the appearance of Fc gamma RI were detected in TB-PMN. In addition, cytotoxicity, superoxide anion release, and TNF-LY and IL-1 beta production were enhanced in TB-PMN. Thus, in tuberculosis, the activation of PMN outside the focus of infection strongly suggeststhe possibility of a systemic inflammation that could modulate the inflammatory response. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 18:14:57