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Titolo:
Cystatin C is an independent predictor of fasting and post-methionine loadtotal homocysteine concentrations among stable renal transplant recipients
Autore:
Aras, O; Tsai, MY; Hanson, NQ; Bailey, R; Rao, GD; Hunninghake, DB;
Indirizzi:
Univ Minnesota, Sch Med, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 Pathol, Minneapolis, MN 55455 USA Univ Minnesota, Sch Med, Dept Surg, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 t Surg, Minneapolis, MN 55455 USA Univ Minnesota, Sch Med, Dept Pharmacol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 rmacol, Minneapolis, MN 55455 USA Univ Minnesota, Sch Med, Dept Med, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 pt Med, Minneapolis, MN 55455 USA
Titolo Testata:
CLINICAL CHEMISTRY
fascicolo: 7, volume: 47, anno: 2001,
pagine: 1263 - 1268
SICI:
0009-9147(200107)47:7<1263:CCIAIP>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLOMERULAR-FILTRATION RATE; NORMAL SERUM CREATININE; CORONARY HEART-DISEASE; PLASMA HOMOCYSTEINE; CARDIOVASCULAR-DISEASE; VASCULAR-DISEASE; RISK FACTOR; FOLIC-ACID; SENSITIVE MARKER; HYPERHOMOCYSTEINEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Tsai, MY 420 Delaware St SE,Mayo Mail Code 609, Minneapolis, MN 55455 USA420 Delaware St SE,Mayo Mail Code 609 Minneapolis MN USA 55455 A
Citazione:
O. Aras et al., "Cystatin C is an independent predictor of fasting and post-methionine loadtotal homocysteine concentrations among stable renal transplant recipients", CLIN CHEM, 47(7), 2001, pp. 1263-1268

Abstract

Background: An increased prevalence of hyperhomocysteinemia with an increased incidence of cardiovascular disease events has been reported among stable renal transplant recipients (RTRs). Preliminary studies in a small number of these individuals have shown that serum creatinine and cystatin C, both markers of kidney function and glomerular filtration rate, are independent determinants of fasting tHcy concentrations; however, determinants of tHcy concentrations after a methionine load have not been studied. Methods: We determined the prevalence of both fasting and 4-h post-methionine load (PML) tHcy concentrations in 78 stable RTRs and compared the role of cystatin C with the role of serum creatinine as determinants of fasting and PML tHcy. Results: Of the 78 RTRs, 21 (26.9%) had fasting and PML tHcy within the respective reference intervals, and 57 (73.1%) had increased plasma tHcy. Of these 57 RTRs, 22 had fasting hyperhomocysteinemia, 9 had PML hyperhomocysteinemia, and 26 had combined hyperhomocysteinemia (both fasting and PML). Unadjusted Pearson correlations showed that fasting plasma tHcy correlated with both cystatin C (r = 0.564; P <0.001) and creatinine (r = 0.519; P <0.001) and that increases in PML tHcy modestly correlated with cystatin (r = 0.205; P = 0.072), but not creatinine (r = 0.057; P = 0.624). General linearregression modeling with stepwise analysis of covariance showed that both cystatin C (partial R = 0.554; P <0.001) and creatinine (partial X = 0.535;P <0.001) were independent predictors of fasting tHcy, but of the two, only cystatin C (partial R = 0.242; P = 0.035) was an independent predictor ofincreased PML tHcy. Conclusions: Clinically stable RTRs have an excess prevalence of moderate hyperhomocysteinemia, and additional cases can be detected by methionine loading. both creatinine and cystatin C are independent predictors of fasting: tHcy in these individuals; however, only cystatin C is a determinant of tHcy concentration after a methionine load, probably because cystatin C is amore sensitive marker of glomerular filtration rate than serum creatinine. (C) 2001 American Association fer Clinical Chemistry.

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Documento generato il 04/07/20 alle ore 05:27:58