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Titolo:
Slow recovery of follicular B cells and marginal zone B cells after chemotherapy: implications for humoral immunity
Autore:
Zandvoort, A; Lodewijk, ME; Klok, PA; Dammers, PM; Kroese, FGM; Timens, W;
Indirizzi:
Univ Groningen Hosp, Dept Pathol & Lab Med, NL-9700 RB Groningen, Netherlands Univ Groningen Hosp Groningen Netherlands NL-9700 RB ningen, Netherlands Univ Groningen Hosp, Dept Histol & Cell Biol, NL-9700 RB Groningen, Netherlands Univ Groningen Hosp Groningen Netherlands NL-9700 RB ningen, Netherlands Univ Groningen, Dept Histol & Cell Biol, NL-9700 RB Groningen, NetherlandsUniv Groningen Groningen Netherlands NL-9700 RB B Groningen, Netherlands Univ Groningen, Dept Pathol & Lab Med, NL-9700 RB Groningen, Netherlands Univ Groningen Groningen Netherlands NL-9700 RB B Groningen, Netherlands
Titolo Testata:
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
fascicolo: 2, volume: 124, anno: 2001,
pagine: 172 - 179
SICI:
0009-9104(200105)124:2<172:SROFBC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOCLONAL-ANTIBODIES; TI-2 ANTIGENS; RAT; SPLEEN; EXPRESSION; DIFFERENTIATION; LOCALIZATION; ACTIVATION; KINETICS; CANCER;
Keywords:
B cells; marginal zone; rat; TI-2 antigens; spleen;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Timens, W Univ Groningen Hosp, Dept Pathol & Lab Med, POB 30-001, NL-9700 RB Groningen, Netherlands Univ Groningen Hosp POB 30-001 Groningen Netherlands NL-9700 RB
Citazione:
A. Zandvoort et al., "Slow recovery of follicular B cells and marginal zone B cells after chemotherapy: implications for humoral immunity", CLIN EXP IM, 124(2), 2001, pp. 172-179

Abstract

Although most chemotherapeutic agents are known to cause primarily reduction or suppression of immune responses, surprisingly little is known about the influence of cytostatic agents on lymphoid tissue compartments such as the splenic marginal zone. The marginal zone plays an important role in the defence against encapsulated bacteria, which are potential candidates for postchemotherapeutic infections. We studied the effect of three different cytostatic agents (cisplatin, methotrexate, and cyclophosphamide) on B cell subpopulations in a rat model. Rats received a single dose of a single cytostatic agent and were sacrificed at different time points after treatment. Bone marrow, blood, mesenteric lymph nodes and spleens were analysed by flow-cytometry and immunohistochemistry. All three cytostatic agents showed severe bone marrow depression. CP and MTX showed only mild reduction of cell populations in the spleen. CyPh showed a severe reduction of recirculating follicular B (RF-B) cells and marginal zone B (MZ-B) cells. At day 24 most populations were already recovered, but RF-B cells and MZ-B cells were stillreduced. The reduction of the marginal zone and late recovery may imply that, beside the overall increased infection risk due to neutropenia, patients treated with chemotherapy are at risk for developing infections from encapsulated bacteria for a considerable period of time after treatment, extending beyond the period of bone marrow depression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 12:56:22