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Titolo:
Efficacy of continuous tracheal gas insufflation in spontaneously breathing canine with acute lung injury
Autore:
Zhan, QY; Wang, C; Shang, MY; Tong, ZH; Weng, XZ;
Indirizzi:
Capital Univ Med Sci, Beijing Inst Resp Med, Beijing Chaoyang Hosp, Beijing 100020, Peoples R China Capital Univ Med Sci Beijing Peoples R China 100020 020, Peoples R China
Titolo Testata:
CHINESE MEDICAL JOURNAL
fascicolo: 6, volume: 114, anno: 2001,
pagine: 658 - 660
SICI:
0366-6999(200106)114:6<658:EOCTGI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
CHI
Soggetto:
CONTROL VENTILATION; PRESSURE-CONTROL; CATHETER; VOLUME;
Keywords:
mechanical ventilation; tracheal gas insufflation; acute lung injury; spontaneous breathing;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
7
Recensione:
Indirizzi per estratti:
Indirizzo: Zhan, QY Capital Univ Med Sci, Beijing Inst Resp Med, Beijing Chaoyang Hosp, Beijing 100020, Peoples R China Capital Univ Med Sci Beijing Peoples RChina 100020 les R China
Citazione:
Q.Y. Zhan et al., "Efficacy of continuous tracheal gas insufflation in spontaneously breathing canine with acute lung injury", CHIN MED J, 114(6), 2001, pp. 658-660

Abstract

Objective To investigate the effects of continuous tracheal gas insufflation (CTGI) combined with biphasic intermittent positive airway pressure (BIPAP) ventilation on dogs with spontaneous breathing. Methods Eight canine models with oleic acid induced lung injury and spontaneous breathing were ventilated in a random order by Evita 2 (Drager Inc., Germany) in modes of BIPAP (BIPAP group) and BIPAP with CTGI flow rate of 3, 6 and 9 L/min (T3, T6 and T9 groups), respectively. The setting parameters of BIPAP were fiction of inspired oxygen 60%, inspiratory to expiratory ratio 1:1, respiratory rate 20 and positive end expiratory pressure 5 cm H2O. Arterial and mixed venous blood gas, lung mechanics, systemic and pulmonary hemodynamics status were monitored at the same level of PaCO2 obtained by adjusting peak inspiratory pressure of BIPAP. Results Peak inspiratory pressure in the T6 group (14 +/- 4 cm H2O) and inthe T9 group (11 +/- 3 cm H2O) were significantly lower than that of BIPAP(20 +/- 5 cm H2O, P < 0.01), but there was no significant difference amongthe T3, T6 and T9 groups or between the T3 and BIPAP groups. PaO2, mean artery blood pressure, mean pulmonary artery pressure, pulmonary artery wedgepressure, cardiac ouput, oxygen delivery and oxygen consumption all remained unchanged in four different conditions. Conclusions Using BIPAP combined with CTGI does not cause asynchrony between ventilator and spontaneous breathing, but significantly decreases airwaypressure with no influence on hemodynamics and oxygenation. Therefore, BIPAP with CTGI may be a useful support technique, especially in cases where the airway pressure should be limited.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 08:04:14