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Titolo:
Tissue-type plasminogen activator and plasminogen activator inhibitor type-1 mRNA and their protein expression levels in human decidua after early pregnancy termination by mifepristone plus misoprostol
Autore:
Huang, LL; Shi, YF;
Indirizzi:
Zhejiang Univ, Womens Hosp, Sch Med, Hangzhou 310006, Peoples R China Zhejiang Univ Hangzhou Peoples R China 310006 ou 310006, Peoples R China
Titolo Testata:
CHINESE MEDICAL JOURNAL
fascicolo: 6, volume: 114, anno: 2001,
pagine: 628 - 631
SICI:
0366-6999(200106)114:6<628:TPAAPA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
CHI
Soggetto:
ENDOTHELIAL-CELLS; MIGRATION; RU-486;
Keywords:
tissue-type plasminogen activator; plasminogen activator inhibitor type-1 mifepristone; decidua; uterine hemorrhage;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Huang, LL Zhejiang Univ, Womens Hosp, Sch Med, Hangzhou 310006, Peoples R China Zhejiang Univ Hangzhou Peoples R China 310006 Peoples R China
Citazione:
L.L. Huang e Y.F. Shi, "Tissue-type plasminogen activator and plasminogen activator inhibitor type-1 mRNA and their protein expression levels in human decidua after early pregnancy termination by mifepristone plus misoprostol", CHIN MED J, 114(6), 2001, pp. 628-631

Abstract

Objective To investigate the mechanism of prolonged uterine hemorrhage after terminating early pregnancy by mifepristone plus misoprostol. Methods Forty-five decidua specimens were obtained from 45 pregnant women with amenorrhea of 6-7 week duration. Fifteen women were treated with mifepristone and 15 were treated with mifepristone plus misoprostol. The remaining 15 served as controls. The tPA and PAI-1 mRNA levels were estimated by reverse transcription-polymerase chain reaction. Chromogenic assay and enzyme-linked immunosorbent assay were used to detect tPA activity and PAI-1 protein level in decidua. Results The activities of tPA in the mifepristone plus misoprostol group and in the mifepristone group were 46.91 +/- 20.74 IU/mg protein and 64.25 +/- 35.81 IU/mg protein respectively, lower than those in the normal deciduagroup (99.76 +/- 58.61 IU/mg protein, P < 0.05). tPA mRNA levels in the mifepristone plus misoprostol group were the highest (1.43 +/- 0.39) among the groups. In the mifepristone group, tPA mRNA level (0.90 +/- 0.16) was notsignificantly different from that in the normal decidua group (0.94 +/- 0.17). The protein and mRNA expression levels of PAI-1 were not significantlydifferent among the three groups (P > 0.05). Conclusions Mifepristone plus misoprostol decreased tPA activity in human early decidua by post-transcription pathways, which may influence decidua shedding, endometrial angiogenesis, endometrial remodeling, and cause prolonged uterine hemorrhage after drug abortion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 21:18:52