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Titolo:
Medicinal flowers. III. Marigold. (1): Hypoglycemic, gastric emptying inhibitory, and gastroprotective principles and new oleanane-type triterpene oligoglycosides, calendasaponins A, B, C, and D, from Egyptian Calendula officinalis
Autore:
Yoshikawa, M; Murakami, T; Kishi, A; Kageura, T; Matsuda, H;
Indirizzi:
Kyoto Pharmaceut Univ, Yamashina Ku, Kyoto 6078412, Japan Kyoto PharmaceutUniv Kyoto Japan 6078412 shina Ku, Kyoto 6078412, Japan
Titolo Testata:
CHEMICAL & PHARMACEUTICAL BULLETIN
fascicolo: 7, volume: 49, anno: 2001,
pagine: 863 - 870
SICI:
0009-2363(200107)49:7<863:MFIM(H>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; OLEANOLIC ACID OLIGOGLYCOSIDES; NATURALLY OCCURRING SUBSTANCES; SENSITIVE SENSORY NERVES; ARALIA-ELATA SEEM; BETA-VULGARIS L; BIOACTIVE SAPONINS; ESCINS IA; MUCOSAL LESIONS; SUGAR-BEET;
Keywords:
calendasponin; Calendula officinalis; marigold; hypoglycemic activity; gastroprotective activity; gastric emptying inhibitory activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Yoshikawa, M Kyoto Pharmaceut Univ, Yamashina Ku, Kyoto 6078412, Japan Kyoto Pharmaceut Univ Kyoto Japan 6078412 to 6078412, Japan
Citazione:
M. Yoshikawa et al., "Medicinal flowers. III. Marigold. (1): Hypoglycemic, gastric emptying inhibitory, and gastroprotective principles and new oleanane-type triterpene oligoglycosides, calendasaponins A, B, C, and D, from Egyptian Calendula officinalis", CHEM PHARM, 49(7), 2001, pp. 863-870

Abstract

The methanolic extract and its 1-butanol-soluble fraction from the flowersof Calendula officinalis were found to show a hypoglycemic effect, inhibitory activity of gastric emptying, and gastroprotective effect. From the 1-butanol-soluble fraction, four new triterpene oligoglycosides, calendasaponins A, B, C, and D, were isolated, together with eight known saponins, sevenknown flavonol glycosides, and a known sesquiterpene glucoside, Their structures were elucidated on the basis of chemical and physicochemical evidence. The principal saponin constituents, glycosides A, B, C, D, and F, exhibited potent inhibitory effects on an increase in serum glucose Levels in glucose-loaded rats, gastric emptying in mice, and ethanol- and indomethacin-induced gastric lesions in rats. Some structure-activity relationships are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 22:41:54