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Titolo:
Adoptive transfer of a superantigen-induced hole in the repertoire of natural IgM-secreting cells
Autore:
Silverman, GJ;
Indirizzi:
Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 pt Med, La Jolla, CA 92093 USA
Titolo Testata:
CELLULAR IMMUNOLOGY
fascicolo: 1, volume: 209, anno: 2001,
pagine: 76 - 80
SICI:
0008-8749(20010410)209:1<76:ATOASH>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
STAPHYLOCOCCUS-AUREUS; PROTEIN-A; BINDING; LYMPHOCYTES; ANTIBODIES; RECEPTORS;
Keywords:
tolerance; repertoire; clonal selection; Ig genes; host immunity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Silverman, GJ Univ Calif San Diego, Dept Med, 9500 Gilman Dr, La Jolla, CA92093 USA Univ Calif San Diego 9500 Gilman Dr La Jolla CA USA 92093 SA
Citazione:
G.J. Silverman, "Adoptive transfer of a superantigen-induced hole in the repertoire of natural IgM-secreting cells", CELL IMMUN, 209(1), 2001, pp. 76-80

Abstract

We have recently evaluated the host response to the bacterial toxin, protein A from Staphylococcus aureus (SpA), which has the capacity to interact with B-cell antigen receptors encoded by VH dan III genes via a conserved variable region framework surface. In these studies, intraperitoneal instillation of SpA induced a persistent T-cell independent loss of a large supraclonal set of susceptible lymphocytes, which includes clan III/V-H S107 family-expressing B-1 cells and their antibody products. To determine whether these long-term effects could represent the influence of residual in vivo deposited superantigen, we have now performed adoptive transfer of peritoneal B cells from superantigen- and control-treated donors. These studies demonstrated that mice that received cells from SpA-treated donors also exhibitedthe same induced supraclonal hole in the expressed repertoire of natural IgM-secreting cells due to supraclonal deletion. These studies clarify the cellular mechanisms responsible for B-cell superantigen-induced modificationof the repertoires of in vivo polyclonal B-cell populations. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 21:47:41