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Titolo:
Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: A humoral mechanism to reset a peripheral clock
Autore:
McNamara, P; Seo, SB; Rudic, RD; Sehgal, A; Chakravarti, D; FitzGerald, GA;
Indirizzi:
Univ Penn, Sch Med, Ctr Expt Therapeut, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Therapeut, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Dept Pharmacol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Pharmacol, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Howard Hughes Med Inst, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Med Inst, Philadelphia, PA 19104 USA Univ Penn, Sch Med, Dept Neurosci, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Neurosci, Philadelphia, PA 19104 USA
Titolo Testata:
CELL
fascicolo: 7, volume: 105, anno: 2001,
pagine: 877 - 889
SICI:
0092-8674(20010629)105:7<877:ROCAMB>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAMMALIAN CIRCADIAN CLOCK; SUPRACHIASMATIC NUCLEUS; DIURNAL-VARIATION; RETINOIC ACID; MESSENGER-RNA; EXPRESSION; LOOP; TISSUES; MICE; GENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: FitzGerald, GA Univ Penn, Sch Med, Ctr Expt Therapeut, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 adelphia, PA 19104 USA
Citazione:
P. McNamara et al., "Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: A humoral mechanism to reset a peripheral clock", CELL, 105(7), 2001, pp. 877-889

Abstract

Circadian clock genes are expressed in the suprachiasmatic nucleus and in peripheral tissues to regulate cyclically physiological processes. Synchronization of peripheral oscillators is thought to involve humoral signals, but the mechanisms by which these are mediated and integrated are poorly understood. We report a hormone-dependent interaction of the nuclear receptors,RAR alpha and RXR alpha, with CLOCK and MOP4. These interactions negatively regulate CLOCK/MOP4: BMAL1-mediated transcriptional activation of clock gene expression in vascular cells. MOP4 exhibits a robust rhythm in the vasculature, and retinoic acid can phase shift Per2 mRNA rhythmicity in vivo and in serum-induced smooth muscle cells in vitro, providing a molecular mechanism for hormonal central of clock gene expression. We propose that circadian or periodic availability of nuclear hormones may play a critical role in resetting a peripheral vascular clock.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 16:40:56