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Titolo:
Intramyocardial delivery of FGF2 in combination with radio frequency transmyocardial revascularization
Autore:
Bao, JL; Naimark, W; Palasis, M; Laham, R; Simons, M; Post, MJ;
Indirizzi:
Harvard Med Sch, Angiogenesis Res Ctr, Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA Harvard Med Sch Boston MA USA 02215 aconess Med Ctr, Boston, MA 02215 USA Boston Sci Corp, Natick, MA USA Boston Sci Corp Natick MA USABoston Sci Corp, Natick, MA USA
Titolo Testata:
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
fascicolo: 3, volume: 53, anno: 2001,
pagine: 429 - 434
SICI:
1522-1946(200107)53:3<429:IDOFIC>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBROBLAST-GROWTH-FACTOR; LASER REVASCULARIZATION; ANGIOGENESIS; MODEL; NEOVASCULARIZATION; DENERVATION; ISCHEMIA; THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Post, MJ Harvard Med Sch, Angiogenesis Res Ctr, Beth Israel Deaconess Med Ctr, Rm SL 423 330 Brookline Ave, Boston, MA 02215 USA Harvard Med Sch Rm SL 423 330 Brookline Ave Boston MA USA 02215 A
Citazione:
J.L. Bao et al., "Intramyocardial delivery of FGF2 in combination with radio frequency transmyocardial revascularization", CATHET C IN, 53(3), 2001, pp. 429-434

Abstract

Therapeutic angiogenesis and percutaneous transmyocardial revascularization (PMR) are potentially synergistic modalities to improve myocardial perfusion. To evaluate the efficiency of FGF2 delivery into an area that has beenradio frequency (RF) ablated, we studied two catheter-based delivery methods, a direct injection system (Stiletto) and a combined RF ablation-delivery system (RF-PMR). Four groups (n = 3/group) of pigs received six transendocardial injections of I-125-FGF2/fluorescent microspheres with either the Stiletto or the RF-PMR catheter. RF-PMR injections were preceded by a 0.6 sec RF ablation step. After either 1 or 24 hr, hearts and other tissues were harvested. Intramyocardial deposition sites were located with UV light and isolated. Specific activity per site was expressed as a percentage of totalactivity injected per site corrected for quenching. Injection site recovery was high for both catheter systems (average = 88%) and systemic uptake was low (< 6% in the liver). FGFS retention was significantly higher with theStiletto than the RF-PMR catheter (Stiletto 1 hr 41% +/- 17%, 24 hr 26% +/- 10%, RF-PMR 1 hr 21% +/- 14%, 24 hr 13% +/- 8%; P < 0.001), principally explained by the differences in catheter design. The Stiletto has a retractable needle and is optimized for intramyocardial delivery, whereas infusion from the RF-PMR device occurs at the endocardial surface and relies on channels created during RF ablation. Overall, FGFS retention after transendocardial intramyocardial delivery by the Stiletto or the RF-PMR system is significantly higher than previously observed for intracoronary, intravenous andintrapericardial delivery. In conclusion, the combination of RF ablation and growth factor delivery using the RF-PMR system is feasible and efficient. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:41:59