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Titolo:
Noninvasive detection of coronary lesions by multislice computed tomography: Results of the new age pilot trial
Autore:
Schroeder, S; Kopp, AF; Baumbach, A; Kuettner, A; Herdeg, C; Rosenberger, A; Selbmann, HK; Claussen, CD; Oberhoff, M; Karsch, KR;
Indirizzi:
Univ Tubingen, Med Clin 3, Dept Internal Med, Div Cardiol, D-72076 Tubingen, Germany Univ Tubingen Tubingen Germany D-72076 ardiol, D-72076 Tubingen, Germany Univ Tubingen, Dept Diagnost Radiol, Div Radiol, Tubingen, Germany Univ Tubingen Tubingen Germany st Radiol, Div Radiol, Tubingen, Germany Univ Bristol, Inst Heart, Bristol, Avon, England Univ Bristol Bristol Avon England ol, Inst Heart, Bristol, Avon, England Univ Tubingen, Inst Med Informat Proc, Tubingen, Germany Univ Tubingen Tubingen Germany nst Med Informat Proc, Tubingen, Germany
Titolo Testata:
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
fascicolo: 3, volume: 53, anno: 2001,
pagine: 352 - 358
SICI:
1522-1946(200107)53:3<352:NDOCLB>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOGRAPHY; ATHEROSCLEROSIS; CARDIOLOGY; RESOLUTION; ARTERIES; CALCIUM; DISEASE; RISK;
Keywords:
multislice computed tomography (MSCT); coronary artery disease (CAD); intracoronary ultrasound (ICUS); diagnostic technology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Schroeder, S Univ Tubingen, Med Clin 3, Dept Internal Med, Div Cardiol, Otfried MuellerStr 10, D-72076 Tubingen, Germany Univ Tubingen Otfried Mueller Str 10 Tubingen Germany D-72076
Citazione:
S. Schroeder et al., "Noninvasive detection of coronary lesions by multislice computed tomography: Results of the new age pilot trial", CATHET C IN, 53(3), 2001, pp. 352-358

Abstract

The reliable noninvasive assessment of coronary artery disease would constitute an important step forward in clinical cardiology. The aim of the New Age pilot trial was to evaluate the diagnostic accuracy of multislice computed tomography (MSCT) in determining coronary lesions. As a gold standard for in vivo plaque detection, intracoronary ultrasound (ICUS) was used. Forty plaques were detected by ICUS in 15 target vessels (LAD, n = 8; RCA, n = 7) in patients assigned for ICUS-guided PTCA. Preinterventional MSCT was performed in all patients and the results were compared to ICUS with regard to lesion detection and quantification. According to ICUS results, the 40 plaques were divided into three groups: group I, mild lesions < 50% (n = 14; 44.36% +/- 5.77%); group II, intermediate lesions 50%-75% (n = 12; 59.18% +/- 9.39%); and group III, severe lesions > 75% (n = 14; 91.47% +/- 3.68%). All MSCT scans showed sufficient image quality for analysis. Thirty of 40 (75%) plaques were detected by MSCT in a first blinded session. After unblinding the ICUS results, the remaining 10 (25%) plaques could be identified. Lesion severity was classified correctly in 34 of 40 (85%) plaques. Plaque calcifications were diagnosed correctly in 16 of 19 (84.2%) plaques. Quantification of vessel size revealed a good correlation to the ICUS results (r(2) 0.68; P = 0.004), Noninvasive MSCT angiography showed good diagnostic accuracy with regard to lesion detection and quantification of vessel sire. The overall good image quality, makes this new technology a promising modality, which might become an alternative diagnostic approach in patients with known or suspected coronary artery disease. (C) 2001 Wiley-Liss, Inc.

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Documento generato il 19/01/20 alle ore 09:31:52