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Titolo:
Metabolic changes in the ischemic penumbra after carotid endarterectomy instroke patients by localized in vivo proton magnetic resonance spectroscopy (H-1-MRS)
Autore:
Kim, GE; Lee, JH; Cho, YP; Kim, ST;
Indirizzi:
Univ Ulsan, Coll Med, Asan Med Ctr, Div Vasc Surg, Seoul, South Korea UnivUlsan Seoul South Korea Med Ctr, Div Vasc Surg, Seoul, South Korea Asan Inst Life Sci, NMR Lab, Seoul, South Korea Asan Inst Life Sci SeoulSouth Korea e Sci, NMR Lab, Seoul, South Korea
Titolo Testata:
CARDIOVASCULAR SURGERY
fascicolo: 4, volume: 9, anno: 2001,
pagine: 345 - 355
SICI:
0967-2109(200108)9:4<345:MCITIP>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
THERAPEUTIC WINDOW; MR SPECTROSCOPY; CEREBRAL-CORTEX; FOCAL ISCHEMIA; RAT-BRAIN; THRESHOLDS; CHOLINE; ARTERY; ACETYLCHOLINE; PERFUSION;
Keywords:
carotid endarterectomy; ischemic penumbra; localized in vivo proton magnetic resonance; spectroscopy (H-1-MRS);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, GE Univ Ulsan, Coll Med, Asan Med Ctr, Div Vasc Surg, 388-1 Poongnap Dong, Seoul, South Korea Univ Ulsan 388-1 Poongnap Dong Seoul South Koreaul, South Korea
Citazione:
G.E. Kim et al., "Metabolic changes in the ischemic penumbra after carotid endarterectomy instroke patients by localized in vivo proton magnetic resonance spectroscopy (H-1-MRS)", CARDIOV SUR, 9(4), 2001, pp. 345-355

Abstract

Carotid endarterectomy (CEA) is known to be effective in reducing recurrent ischemic attacks, sometimes accompanied with the functional improvement, for patients with internal carotid artery (ICA) flow lesions by increase inperfusion and/or removal of embolic sources. However, the exact mechanism of how the CEA affects the cerebral metabolism in relations to the perfusion increase in noninfarcted hypoperfused peripheral areas to the center of the lesion (e.g., ischemic penumbra or border zone) is not yet clearly known, The existence of the ischemic penumbra and its long-term viability has also been argued, We designed a prospective study to investigate the metabolic changes in the ischemic penumbra for patients with ICA flow lesions and cerebral infarct (or ischemia) before and after CEA using localized in vivo proton magnetic resonance spectroscopy (H-1-MRS), The results of H-1-MRS showed significantly decreased choline (Cho)/creatine (Cr) and increased N-acetylaspartate (NAA)/Cho ratios in the periphery of the lesion for the patients after CEA as compared to those who underwent only medical treatments. The more significant changes in the cerebral metabolite levels were observedin the patients who showed the improved cerebral perfusion by single photon emission computed tomography after CEA than in those who did not. In conclusion, our data suggest the existence of the ischemic penumbra, which wereviable for a longer period than previously thought; CEA seems to improve the cerebral metabolism that may result from the improved perfusion at the ischemic penumbra, (C) 2001 The International Society for Cardiovascular Surgery, Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:55:23