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Titolo:
Overexpression of KAI1 suppresses in vitro invasiveness and in vivo metastasis in breast cancer cells
Autore:
Yang, XH; Wei, LL; Tang, C; Slack, R; Mueller, S; Lippman, ME;
Indirizzi:
Georgetown Univ, Med Ctr, Vincent T Lombardi Canc Res Ctr, Washington, DC 20007 USA Georgetown Univ Washington DC USA 20007 Res Ctr, Washington, DC 20007 USA
Titolo Testata:
CANCER RESEARCH
fascicolo: 13, volume: 61, anno: 2001,
pagine: 5284 - 5288
SICI:
0008-5472(20010701)61:13<5284:OOKSIV>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-EXPRESSION; LUNG-CANCER; TUMOR-CELLS; MRP-1/CD9; MOTILITY; PROTEIN; TRANSFECTION; PROGRESSION; SUPERFAMILY; ANTIBODIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Lippman, ME Univ Michigan, Hlth Syst, Dept Internal Med, Taubman Hlth Ctr 3101, 1500 EMed Ctr Dr, Ann Arbor, MI 48109 USA Univ Michigan 1500 E Med Ctr Dr Ann Arbor MI USA 48109 109 USA
Citazione:
X.H. Yang et al., "Overexpression of KAI1 suppresses in vitro invasiveness and in vivo metastasis in breast cancer cells", CANCER RES, 61(13), 2001, pp. 5284-5288

Abstract

KAI1 is a metastasis suppressor gene for human prostate cancer and is alsoinvolved in the progression of a variety of other human cancers. Previously,, we have demonstrated that KAI1 expression was down-regulated in metastatic breast cancer cell lines as well as in highly aggressive breast cancer specimens, To determine whether KAI1 expression is responsible for the metastasis suppression in breast cancer, me transfected the human KAI1 cDNA into two highly malignant breast cancer cell lines, LCC6 and MDA-MB-231, whichboth have low levels of endogenous KAI1 expression. Parental, vector-only transfectants and KAII transfectant clones were injected into the mammary fat pads and tail veins, respectively, of athymic nude mice and assessed forboth spontaneous and experimental lung metastasis, High KBI1 expression significantly suppressed the metastatic potential of KAI1-transfected LCC6 cells. Metastasis suppression correlated with the reduced rate of tumor growth and a decreased clonogenicity in soft agar, Furthermore, KAI1 expression significantly suppressed the in vitro cell invasion in KAI1-transfected MDA-MB-231 cells. Our results suggested that KAI1 may function as a negative regulator of breast cancer metastasis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:45:45