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Titolo:
Expression of a tumor-associated antigen RCAS1 in hepatocellular carcinoma
Autore:
Noguchi, K; Enjoji, M; Nakamuta, M; Nakashima, M; Nishi, H; Choi, I; Taguchi, K; Kotoh, K; Shimada, M; Sugimachi, K; Tsuneyoshi, M; Nawata, H; Watanabe, T;
Indirizzi:
Kyushu Univ, Grad Sch Med Sci, Dept Med & Bioregulatory Sci, Higashi Ku, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 ci, Higashi Ku, Fukuoka 8128582, Japan Kyushu Univ, Med Inst Bioregulat, Dept Mol Immunol, Higashi Ku, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 ol, Higashi Ku, Fukuoka 8128582, Japan Kyushu Univ, Fac Med, Dept Surg 2, Higashi Ku, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 2, Higashi Ku, Fukuoka 8128582, Japan
Titolo Testata:
CANCER LETTERS
fascicolo: 2, volume: 168, anno: 2001,
pagine: 197 - 202
SICI:
0304-3835(20010726)168:2<197:EOATAR>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN UTERINE; FAS LIGAND; ADENOCARCINOMA; CELLS; CHOLANGIOCARCINOMA; APOPTOSIS; CANCER;
Keywords:
hepatocellular carcinoma; tumor-associated antigen; vascular invasion; monoclonal antibody;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Enjoji, M Kyushu Univ, Grad Sch Med Sci, Dept Med & Bioregulatory Sci, Higashi Ku, Maidashi 3-1-1, Fukuoka 8128582, Japan Kyushu Univ Maidashi 3-1-1 Fukuoka Japan 8128582 8128582, Japan
Citazione:
K. Noguchi et al., "Expression of a tumor-associated antigen RCAS1 in hepatocellular carcinoma", CANCER LETT, 168(2), 2001, pp. 197-202

Abstract

RCAS1 has been reported as a tumor-associated antigen in uterine and ovarian carcinomas. In vitro studies on RCAS1 indicated that it might function as an apoptosis-inducing factor since binding between RCAS1 and its receptorinduced apoptosis in receptor-expressing cells. In this study, 68 surgically resected samples of hepatocellular carcinoma (HCC) were prepared and RCAS1 expression was examined immunohistochemically, because RCAS1 was also positive in all HCC cell lines tested. Clinical and pathological parameters were then compared between RCAS1-positive and -negative HCC cases. As a result, RCAS1 is expressed in 26.5% of HCC cases and vascular invasion is observed at a much higher rate in the RCAS 1positive cases (72.2%) than in RCAS 1-negative cases (24.0%). RCAS 1 is not an antigen specific for gynecological cancers. In HCC cases, the RCAS1-positive percentage is not high, however, RCAS1-positive HCCs exhibited a trend towards invasive character. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 17:48:21