Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Functional maturation of dendritic cells by exposure to CD40L transgenic tumor cells, fibroblasts or keratinocytes
Autore:
Felzmann, T; Buchberger, M; Lehner, M; Printz, D; Kircheis, R; Wagner, E; Gadner, H; Holter, W;
Indirizzi:
St Anna Childrens Hosp, Childrens Canc Res Inst, A-1090 Vienna, Austria StAnna Childrens Hosp Vienna Austria A-1090 nst, A-1090 Vienna, Austria Boehringer Ingelheim Austria, A-1120 Vienna, Austria Boehringer Ingelheim Austria Vienna Austria A-1120 -1120 Vienna, Austria
Titolo Testata:
CANCER LETTERS
fascicolo: 2, volume: 168, anno: 2001,
pagine: 145 - 154
SICI:
0304-3835(20010726)168:2<145:FMODCB>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-LYMPHOCYTES; GENE DELIVERY; EXPRESSION; MOLECULES; LIGAND; POLYETHYLENIMINE; INTERLEUKIN-12; ADENOVIRUS; COMPLEXES; IMMUNITY;
Keywords:
CD154; polyethylenimine; adenovirus-enhanced transferrinfection; gene transfer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Felzmann, T St Anna Childrens Hosp, Childrens Canc Res Inst, Kinderspitalgasse 6, A-1090 Vienna, Austria St Anna Childrens Hosp Kinderspitalgasse 6 Vienna Austria A-1090
Citazione:
T. Felzmann et al., "Functional maturation of dendritic cells by exposure to CD40L transgenic tumor cells, fibroblasts or keratinocytes", CANCER LETT, 168(2), 2001, pp. 145-154

Abstract

Tumor antigen pulsed dendritic cells (DCs) can induce anti-tumor immunity. We studied strategies for the reliable generation of such a tumor vaccine by functional maturation of DCs via interaction of CD40 with its ligand (CD40L, CD154). Exposure of immature DCs to CD40L transgenic cells, soluble recombinant human CD40L molecules or lipopolysaccharide induced expression ofthe co-stimulatory molecules, CD80 and CD86, and supported an allogeneic mixed leukocyte reaction. In contrast, the release of IL-12, an important mediator of anti-tumor immunity, and antigen-specific expansion and IFN gammasecretion of lymphocytes, was strongly triggered only by DCs exposed to CD40L transgenic cells. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 04:15:28