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Titolo:
Attenuation by ambroxol of monochloramine-enhanced gastric carcinogenesis:a possible prevention against Helicobacter pylori-associated gastric carcinogenesis
Autore:
Narahara, H; Tatsuta, M; Iishi, H; Baba, M; Mikuni, T; Uedo, N; Sakai, N; Yano, H;
Indirizzi:
Osaka Med Ctr Canc & Cardiovasc Dis, Dept Gastrointestinal Oncol, Higashinari Ku, Osaka 5378511, Japan Osaka Med Ctr Canc & Cardiovasc Dis Osaka Japan 5378511 a 5378511, Japan
Titolo Testata:
CANCER LETTERS
fascicolo: 2, volume: 168, anno: 2001,
pagine: 117 - 124
SICI:
0304-3835(20010726)168:2<117:ABAOMG>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOCLONAL-ANTIBODY; IN-VITRO; CARCINOMA; INFECTION; SCAVENGER; APOPTOSIS; CELLS; YOUNG; RISK; RATS;
Keywords:
ambroxol; gastric carcinogenesis; monochloramine; N-methyl-N '-nitro-N-nitrosoguanidine; Helicobacter pylori;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Narahara, H Osaka Med Ctr Canc & Cardiovasc Dis, Dept Gastrointestinal Oncol, Higashinari Ku, 3-3 Nakamichi 1 Chome, Osaka 5378511, Japan Osaka Med Ctr Canc & Cardiovasc Dis 3-3 Nakamichi 1 Chome Osaka Japan 5378511
Citazione:
H. Narahara et al., "Attenuation by ambroxol of monochloramine-enhanced gastric carcinogenesis:a possible prevention against Helicobacter pylori-associated gastric carcinogenesis", CANCER LETT, 168(2), 2001, pp. 117-124

Abstract

The effects of combined administration of a reactive oxidant, monochloramine, and a mucoregulatory agent, ambroxol, on the development of gastric cancers induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) were investigated in inbred Wistar rats. After receiving oral MNNG and regular chow pellets for 25 weeks, rats received regular chow pellets or chow pellets containing 20% ammonium acetate, and normal tap water or water containing 30 mM sodium hypochlorite, with or without subcutaneous injection of ambroxol at high or low doses, until the end of the experiment at week 52. Treatment with both ammonium acetate and sodium hypochlorite, which produce monochloramine, significantly increased the incidence of gastric cancers at week 52, whereas concomitant administration of ambroxol with ammonium acetate and sodiumhypochlorite significantly attenuated this enhanced gastric carcinogenesis. Results also revealed that ambroxol scavenged monochloramine. Because monochloramine is closely related to Helicobacter pylori-associated gastric carcinogenesis, these findings suggest that ambroxol may prevent H, pylori-associated gastric carcinogenesis. (C) 2001 Elsevier Science ireland Ltd. Allrights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 06:31:28