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Titolo:
Fluoropyrimidine sensitivity of human MCF-7 breast cancer cells stably transfected with human uridine phosphorylase
Autore:
Cuq, P; Rouquet, C; Evrard, A; Ciccolini, J; Vian, L; Cano, JP;
Indirizzi:
Fac Pharm Montpellier, Lab Toxicol Medicament, F-34060 Montpellier 02, France Fac Pharm Montpellier Montpellier France 02 34060 Montpellier 02, France Lab Toxicocinet & Pharmacocinet, F-13385 Marseille, France Lab Toxicocinet& Pharmacocinet Marseille France F-13385 rseille, France
Titolo Testata:
BRITISH JOURNAL OF CANCER
fascicolo: 12, volume: 84, anno: 2001,
pagine: 1677 - 1680
SICI:
0007-0920(20010615)84:12<1677:FSOHMB>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYMIDINE-PHOSPHORYLASE; GROWTH-FACTOR; IN-VITRO; ANTITUMOR-ACTIVITY; 5'-DEOXY-5-FLUOROURIDINE; 5-FLUOROURACIL; EXPRESSION; ENHANCEMENT; CARCINOMA; CYTOTOXICITY;
Keywords:
uridine phosphorylase; breast cancer; 5-FU; 5 ' DFUR; cancer gene therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Cuq, P Fac Pharm Montpellier, Lab Toxicol Medicament, 15 Ave Charles Flahault, F-34060 Montpellier 02, France Fac Pharm Montpellier 15 Ave Charles Flahault Montpellier France 02
Citazione:
P. Cuq et al., "Fluoropyrimidine sensitivity of human MCF-7 breast cancer cells stably transfected with human uridine phosphorylase", BR J CANC, 84(12), 2001, pp. 1677-1680

Abstract

The relationship between uridine phosphorylase (UP) expression level in cancer cells and the tumour sensitivity to fluoropyrimidines is unclear. In this study, we found that UP overexpression by gene transfer, and the subsequent efficient metabolic activation of 5-fluorouracil (5-FU) by the ribonucleotide pathway, does not increase the fluoropyrimidine sensitivity of MCF-7 human cancer cells. (C) 2001 Cancer Research Campaign.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 20:06:20