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Titolo:
Concentration of vascular endothelial growth factor in the tumour tissue as a prognostic factor of soft tissue sarcomas
Autore:
Yudoh, K; Kanamori, N; Ohmori, K; Yasuda, T; Aoki, M; Kimura, T;
Indirizzi:
Toyama Med & Pharmaceut Univ, Dept Orthopaed Surg, Toyama, Japan Toyama Med & Pharmaceut Univ Toyama Japan Orthopaed Surg, Toyama, Japan
Titolo Testata:
BRITISH JOURNAL OF CANCER
fascicolo: 12, volume: 84, anno: 2001,
pagine: 1610 - 1615
SICI:
0007-0920(20010615)84:12<1610:COVEGF>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERMEABILITY FACTOR; GASTRIC-CARCINOMA; ANGIOGENESIS; EXPRESSION; CANCER; METASTASIS; CELLS; KDR; NEOVASCULARIZATION; RECEPTOR;
Keywords:
microvessel density; vascular endothelial growth factor; overall survival; tumour recurrence; metastasis; soft tissue sarcoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Yudoh, K Toyama Med & Pharmaceut Univ, Dept Orthopaed Surg, Toyama, Japan Toyama Med & Pharmaceut Univ Toyama Japan Surg, Toyama, Japan
Citazione:
K. Yudoh et al., "Concentration of vascular endothelial growth factor in the tumour tissue as a prognostic factor of soft tissue sarcomas", BR J CANC, 84(12), 2001, pp. 1610-1615

Abstract

Previous studies have shown that the prognosis of patients who have tumours with high microvessel density (MVD) is worse than that of patients who have a lower density in a variety of cancers. In this study, we investigated the clinical relevance of neovascularity assessed by MVD and the concentration of vascular endothelial growth factor (WEGF) in the tumour tissue of patients with soft tissue sarcoma in comparison with major clinicohistologic parameters by univariate and multivariate analysis. In 115 patients with soft tissue sarcoma, MVD was measured by counting vessels stained with factorVIII antibody. The concentration of VEGF in the tumour tissue was determined by enzyme-linked immunosorbent assay. These parameters were then compared with disease outcome. The concentration of VEGF in the tumour tissue, butnot MVD, was round to be correlated with disease outcome in patients with soft tissue, sarcoma. VEGF concentration in the tumour tissue showed a relationship with the clinical stage and histologic grade of the tumour. There was no significant difference in the levels of tissue VEGF concentration and MVD among soft tissue sarcomas classified according to histologic type. The level of tissue VEGF concentration in patients who had subsequent local recurrence and metastasis were significantly higher than the respective values in patients who did not have such disease outcome. No significant correlation existed between MVD and the concentration of VEGF in the tumour tissue. Univariate analysis showed that a high tissue VEGF concentration was associated with poor overall survival of the patient and a greater probability that local recurrence and metastasis had occurred. Multivariate analysis revealed that the tissue concentration of VEGF is an independent prognosticfactor for the disease outcome of patients with sofi tissue sarcoma. VEGF concentration in the tumour tissue, but not MVD, is an additional prognostic parameter for disease outcome in patients with soft tissue sarcoma, regardless of histologic type. (C) 2001 Cancer Research Campaign.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 10:20:04