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Titolo:
Caffeine reverses the memory disruption induced by intra-nigral MPTP-injection in rats
Autore:
Gevaerd, MS; Takahashi, RN; Silveira, R; Da Cunha, C;
Indirizzi:
UFPR, Dept Farmacol, Lab Fisiol & Farmacol, SNC, BR-81531990 Curitiba, Parana, Brazil UFPR Curitiba Parana Brazil BR-81531990 BC531990 Curitiba, Parana, Brazil USP, Dept Psicobiol, Fac Filosofia Ciencias & Letras, Ribeirao Preto, Brazil USP Ribeirao Preto Brazil fia Ciencias & Letras, Ribeirao Preto, Brazil UFPR, Dept Farmacol, Lab Fisiol & Farmacol, SNC, Curitiba, Parana, Brazil UFPR Curitiba Parana Brazil ol & Farmacol, SNC, Curitiba, Parana, Brazil
Titolo Testata:
BRAIN RESEARCH BULLETIN
fascicolo: 1, volume: 55, anno: 2001,
pagine: 101 - 106
SICI:
0361-9230(20010501)55:1<101:CRTMDI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADENOSINE A(2A) RECEPTORS; PARKINSONS-DISEASE; STRIATAL MEMBRANES; HUMAN-PERFORMANCE; ANIMAL-MODEL; BEHAVIOR; A(1); COMBINATION; STIMULATION; ANTAGONISTS;
Keywords:
Parkinson's disease; MPTP; caffeine; learning; memory; cognition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Da Cunha, C UFPR, Dept Farmacol, Lab Fisiol & Farmacol, SNC, CP 19-031, BR-81531990 Curitiba, Parana, Brazil UFPR CP 19-031 Curitiba Parana Brazil BR-81531990 BCna, Brazil
Citazione:
M.S. Gevaerd et al., "Caffeine reverses the memory disruption induced by intra-nigral MPTP-injection in rats", BRAIN RES B, 55(1), 2001, pp. 101-106

Abstract

The present study was carried out to test the possible effects of caffeinein improving the memory deficits observed in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP)-lesioned rats, an animal model of early stage Parkinson's disease. Caffeine at the doses of 0.1-0.3 mg/kg (Intraperitoneal) reversed the impairing effect of the administration of MPTP (1 mu rmol/side) into the substantia nigra, compact part, of rats on the avoidance scores inthe training and test sessions of a two-way active avoidance task, This effect was not due to a motor or sensory alteration because the caffeine-induced learning and memory improvement was independent of the locomotor stimulant effect of the drug and there were no differences in the reaction time of the animals to a footshock (unconditioned stimulus) or a sound cue (conditioned stimulus) after caffeine treatment. These results suggest that the reported dopamine/adenosine-receptor interaction can be used to restore defective learning and memory processes in Parkinson's disease and indicate that caffeine and other adenosine receptor antagonists are drugs with the potential for treatment of the cognitive disabilities of Parkinson's disease. (C) 2001 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:24:54