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Titolo:
A comparative neuroethological study of limbic seizures induced by Parawixia bistriata venom and kainic acid injections in rats
Autore:
Rodrigues, MCA; Guizzo, R; dos Santos, WF; Cairasco, NG;
Indirizzi:
Univ Sao Paulo, Lab Neurofisiol & Neuroetol Expt, Dept Fisiol, Fac Med Ribeirao Preto, BR-14049900 Ribeirao Preto, SP, Brazil Univ Sao Paulo Ribeirao Preto SP Brazil BR-14049900 BCo Preto, SP, Brazil Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Psicol & Educ, Programa Posgraduacao Psicobiol, Ribeirao Preto, Brazil Fac Filosofia Ciencias & Letras Ribeirao Preto Ribeirao Preto Brazil il Fac Filosofia Ciencias & Letras Ribeirao Preto, Lab Neurobiol & Peconhas, Dept Biol, Ribeirao Preto, Brazil Fac Filosofia Ciencias & Letras Ribeirao Preto Ribeirao Preto Brazil il
Titolo Testata:
BRAIN RESEARCH BULLETIN
fascicolo: 1, volume: 55, anno: 2001,
pagine: 79 - 86
SICI:
0361-9230(20010501)55:1<79:ACNSOL>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERRULATUS SCORPION-VENOM; CENTRAL-NERVOUS-SYSTEM; AUDIOGENIC-SEIZURES; SPIDER VENOM; CRUDE VENOM; WISTAR RATS; DENDROTOXIN; RECEPTORS; BRAIN; TOXIN;
Keywords:
Parawixia bistriata; limbic seizures; kainic acid; neuroethology; spider venom; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Cairasco, NG Univ Sao Paulo, Lab Neurofisiol & Neuroetol Expt, Dept Fisiol, Fac Med Ribeirao Preto, Av Bandeirantes 3900, BR-14049900 Ribeirao Preto,SP, Brazil Univ Sao Paulo Av Bandeirantes 3900 Ribeirao Preto SP Brazil BR-14049900 BC
Citazione:
M.C.A. Rodrigues et al., "A comparative neuroethological study of limbic seizures induced by Parawixia bistriata venom and kainic acid injections in rats", BRAIN RES B, 55(1), 2001, pp. 79-86

Abstract

A number of neurotoxins derived from arthropod venoms are known to show highly selective effects on nervous tissue. These neurotoxins have been proved to be extremely useful tools to investigate either convulsive or anticonvulsive mechanisms in the nervous system. In the present work, intracerebroventricular injection of the crude venom from the spider Parawixia bistriata(Araneae, Araneidae) in rats induced convulsive limbic seizures (head and forelimb myoclonus, as well as rearing and falling), Neuroethological analysis showed that the limbic seizures induced by the venom were different from those induced by kainic acid. Intravenous injection of the same venom didnot induce seizures, but the neuroethological analysis showed an intensification of grooming behavior similar to a displaced activity. In conclusion,our experiments point that crude venom of P, bistriata may contain convulsant neurotoxins probably acting in limbic system structures. The mechanism of action of these neurotoxins may be different from simple activation of glutamatergic kainate receptors, as evidenced by a comparative neuroethological analysis of seizures induced by either venom or kainic acid. (C) 2001 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:10:23