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Titolo:
Differential alteration of NMDA receptor subunits in the gerbil dentate gyrus and subiculum following seizure
Autore:
Suh, JG; Ryoo, ZW; Won, MH; Oh, YS; Kang, TC;
Indirizzi:
Hallym Univ, Coll Med, Dept Anat, Chunchon 200702, South Korea Hallym Univ Chunchon South Korea 200702 at, Chunchon 200702, South Korea Sch Med, Catholic Res Inst, Dept Lab Anim Res, Seoul 137701, South Korea Sch Med Seoul South Korea 137701 Lab Anim Res, Seoul 137701, South Korea Hallym Univ, Coll Med, Expt Anim Ctr, Chunchon 200702, South Korea Hallym Univ Chunchon South Korea 200702 tr, Chunchon 200702, South Korea
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1, volume: 904, anno: 2001,
pagine: 104 - 111
SICI:
0006-8993(20010615)904:1<104:DAONRS>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; CELL-SURFACE EXPRESSION; CA1 PYRAMIDAL NEURONS; AMINO-ACID RECEPTORS; ENTORHINAL CORTEX; HIPPOCAMPAL EPILEPSY; GENE-EXPRESSION; RAT HIPPOCAMPUS; SPLICE VARIANTS; GLUTAMATE;
Keywords:
NMDA receptor; hippocampus; dentate gyrus; subiculum; gerbil; epilepsy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Kang, TC Hallym Univ, Coll Med, Dept Anat, Chunchon 200702, South Korea Hallym Univ Chunchon South Korea 200702 hon 200702, South Korea
Citazione:
J.G. Suh et al., "Differential alteration of NMDA receptor subunits in the gerbil dentate gyrus and subiculum following seizure", BRAIN RES, 904(1), 2001, pp. 104-111

Abstract

In the present study, a chronological and comparative analysis of the immunoreactivities of N-methyl-D-aspartate (NMDA) receptor subunits in hippocampus; of both seizure resistant (SR) and seizure sensitive (SS) gerbils was made in order to clarify, the temporal and spatial alterations of NMDA receptor subunit expressions in the hippocampus complex. The changes in NMDA receptor immunoreactivity in the hippocampi of SS gerbils were restricted to both the dentate gyrus and the subiculum. At 30 min postictal, a decline inNMDA receptor subunit 1 (NR1) immunoreactivity in the suprablade of dentate gyrus was observed. This is in contrast to the enhancement of its immunodensity in the infrablade. At 3 h postietal the NRL immunoreactivity in the infrablade also declined significantly. At 12 h postietal, its immunoreactivity in the hilar neurons was reduced. The NMDA receptor subunit 2A/B (NR2A/B) immunoreactivity did not alter until 12 h following seizure-onset, whenit was slightly decreased in the granule cells and hilar neurons. In the subiculum, NR1 immunoreactivity was significantly decreased, and was almost undetectable in this region until 12 h postietal: in contrast the NR2A/B immunoreactivity in this region increased significantly in this time point. These results suggest that the altering NMDA receptor expression in both thedentate gyrus and subiculum may affect tissue excitability and have an important role in regulating seizure activity in SS gerbils. (C) 2001 ElsevierScience B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 07:24:18