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Titolo:
Stimulus time-locked responses of motoneurons during forelimb fictive locomotion evoked by repetitive stimulation of the lateral funiculus
Autore:
Kinoshita, M; Yamaguchi, T;
Indirizzi:
Yamagata Univ, Grad Sch Engn, Yonezawa, Yamagata 9928510, Japan Yamagata Univ Yonezawa Yamagata Japan 9928510 wa, Yamagata 9928510, Japan Univ Tsukuba, Inst Basic Med Sci, Tsukuba, Ibaraki 3050004, Japan Univ Tsukuba Tsukuba Ibaraki Japan 3050004 sukuba, Ibaraki 3050004, Japan
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1, volume: 904, anno: 2001,
pagine: 31 - 42
SICI:
0006-8993(20010615)904:1<31:STROMD>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONJUGATED HORSERADISH-PEROXIDASE; INTERNEURONS CONTROLLING ACTIVITY; PATHWAYS CONTROLLING FORELIMB; C3-C4 PROPRIOSPINAL NEURONS; SPINAL-CORD LESIONS; SPINODELTOIDEUS MOTONEURONS; TRANSNEURONAL TRANSPORT; DECEREBRATE CATS; RENSHAW CELLS; CERVICAL CORD;
Keywords:
central pattern generator; stepping; decerebrate cat; intracellular recording; stimulus-locked response;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Yamaguchi, T Yamagata Univ, Grad Sch Engn, Yonezawa, Yamagata 9928510, Japan Yamagata Univ Yonezawa Yamagata Japan 9928510 9928510, Japan
Citazione:
M. Kinoshita e T. Yamaguchi, "Stimulus time-locked responses of motoneurons during forelimb fictive locomotion evoked by repetitive stimulation of the lateral funiculus", BRAIN RES, 904(1), 2001, pp. 31-42

Abstract

In cat forelimb fictive locomotion evoked by repetitive stimulation of theupper cervical lateral funiculus, locomotor discharges consisted of activities time-locked to each stimulus, which were rhythmically modulated. The stimulus time-locked activities were investigated by intracellular recordingfrom motoneurons. In both elbow flexor and extensor motoneurons, there observed stimulus time-locked disynaptic EPSPs, trisynaptic IPSPs and polysynaptic EPSPs, all of which were rhythmically modulated with specific patterns. The disynaptic EPSPs of flexor motoneurons were facilitated in the flexorphase of locomotion, whereas those of extensor motoneurons were facilitated from the flexor phase to the flexor-to-extensor transition phase. Modulation depth was larger in flexor motoneurons. Trisynaptic IPSPs changed in amplitude in parallel with the disynaptic EPSPs of the antagonistic motoneurons. Late, polysynaptic EPSPs of both flexor and extensor motoneurons increased in amplitude along with corresponding nerve discharges. After lesions of the lateral funiculus at C6/C7, both the disynaptic EPSPs and trisynapticIPSPs were abolished in the motoneurons located caudally to the lesions. However, only trisynaptic IPSPs were lost in the rostrally located motoneurons. Furthermore, the lesions disclosed that extensor motoneurons received another kind of stimulus time-locked EPSPs, trisynaptic EPSPs, which were transmitted through the ventral part of the spinal cord, and rhythmically facilitated in the extensor phase. Stimulus time-locked PSPs observed in this study may at least in part be evoked by last-order interneurons of the central pattern generator, which may be reciprocally organized. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 22:59:04