Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Spatial learning induces neurotrophin receptor and synapsin I in the hippocampus
Autore:
Gomez-Pinilla, F; So, V; Kesslak, JP;
Indirizzi:
Univ Calif Los Angeles, Dept Physiol Sci, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA UCI, Dept Neurol, Inst Brain Aging, Los Angeles, CA USA UCI Los Angeles CA USA ept Neurol, Inst Brain Aging, Los Angeles, CA USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1, volume: 904, anno: 2001,
pagine: 13 - 19
SICI:
0006-8993(20010615)904:1<13:SLINRA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; SYNAPTIC TRANSMISSION; ADULT HIPPOCAMPUS; RAT HIPPOCAMPUS; BDNF; BRAIN; EXPRESSION; INDUCTION; MICE; MODULATION;
Keywords:
rat; neural activity; exercise; neurotrophin; lifestyle; synaptogenesis; use-dependent plasticity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Gomez-Pinilla, F Univ Calif Los Angeles, Dept Physiol Sci, Los Angeles, CA90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 0095 USA
Citazione:
F. Gomez-Pinilla et al., "Spatial learning induces neurotrophin receptor and synapsin I in the hippocampus", BRAIN RES, 904(1), 2001, pp. 13-19

Abstract

We report that rats learning a spatial memory task in the Morris water maze show elevated expression of the signal transduction receptor for BDNF andthe synaptic associated protein synapsin I in the hippocampus. Nuclease protection assays showed maximal levels of TrkB and synapsin I mRNAs in the hippocampus by the time that asymptotic learning performance had been reached (Day 6). Increases in synapsin I mRNA were matched by changes in synapsinI protein as revealed by western blot analysis. Synapsin I is a downstreameffector for the BDNF tyrosine kinase cascade pathway which has important roles in synaptic remodeling and function. Therefore, parallel changes in TrkB and synapsin I mRNAs suggest a role of the BDNF system in synaptic function or adaptation. Levels of TrkB mRNA in the hippocampus were attenuated after learning acquisition (Day 20), but synapsin I mRNA was still elevated, suggesting that the BDNF system may participate in events secondary to learning, such as strengthening of neural circuits. TrkB and synapsin I mRNAsshowed an increasing trend in the cerebellum of learning rats and no changes were observed in the caudal cerebral cortex. The selectivity of the changes in trkB and synapsin I, affecting the hippocampus, is in agreement withthe role of this structure in processing of spatial information. Behavioral regulation of neurotrophins may provide a molecular basis for the enhanced cognitive function associated with active lifestyles, and guide development of strategies to promote neural healing after CNS injury or disease. (C)2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:58:33