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Titolo:
Glucosylceramide synthesis inhibitors block pharmacologically induced dispersal of the Golgi and anterograde membrane flow from the endoplasmic reticulum: Implication of sphingolipid metabolism in maintenance of the Golgi architecture and anterograde membrane flow
Autore:
Nakamura, M; Kuroiwa, N; Kono, Y; Takatsuki, A;
Indirizzi:
RIKEN, Inst Phys & Chem Res, Anim & Cellular Syst Lab, Wako, Saitama 3510198, Japan RIKEN Wako Saitama Japan 3510198 r Syst Lab, Wako, Saitama 3510198, Japan Ibaraki Univ, Sch Agr, Ami, Ibaraki 3000332, Japan Ibaraki Univ Ami Ibaraki Japan 3000332 h Agr, Ami, Ibaraki 3000332, Japan Tokyo Univ Pharm & Life Sci, Sch Life Sci, Hachioji, Tokyo 1920392, Japan Tokyo Univ Pharm & Life Sci Hachioji Tokyo Japan 1920392 o 1920392, Japan
Titolo Testata:
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
fascicolo: 6, volume: 65, anno: 2001,
pagine: 1369 - 1378
SICI:
0916-8451(200106)65:6<1369:GSIBPI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
BREFELDIN-A; NORDIHYDROGUAIARETIC ACID; RETROGRADE TRANSPORT; ORGANELLE STRUCTURE; GUANINE-NUCLEOTIDE; PROTEIN-TRANSPORT; SECRETORY PATHWAY; COMPLEX; APPARATUS; ER;
Keywords:
retrograde membrane flow; anterograde membrane flow; sphingolipid metabolism; PDMP; brefeldin A;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Takatsuki, A RIKEN, Inst Phys & Chem Res, Anim & Cellular Syst Lab, Hirosawa 2-1, Wako,Saitama 3510198, Japan RIKEN Hirosawa 2-1 Wako Saitama Japan 3510198 3510198, Japan
Citazione:
M. Nakamura et al., "Glucosylceramide synthesis inhibitors block pharmacologically induced dispersal of the Golgi and anterograde membrane flow from the endoplasmic reticulum: Implication of sphingolipid metabolism in maintenance of the Golgi architecture and anterograde membrane flow", BIOS BIOT B, 65(6), 2001, pp. 1369-1378

Abstract

PDMP (D,L-threo-1-phenyl-2-decanoylamino-3-mpholino-l-propanol) and PPMP (D,L-threo-l-phenyl-2hexadecanoglamino-3-morpholino-l-propano inhibitors of glucosylceramide synthesis, blocked brefeldin A (BFA)- and nordihydroguaiaretic acid-induced dispersal of the Golgi and trans Golgi network, and Golgi-derived vesicles were retained in the juxtanuclear region. PDMP and PPMP did not stabilize microtubules but blocked nocodazole-induced extensive fragmentation and dispersal of the Golgi, and large Golgi vesicles were retained in the juxtanuclear region. PPMP is a stronger inhibitor of glucosylceramide synthesis than PDMP, but PDMP showed a stronger activity against BFA-induced retrograde membrane how, However, PPMP showed a stronger activity forGolgi disruption and inhibition of anterograde trafficking from the endoplasmic reticulum, and rebuilding of the Golgi architecture. Cumulatively, these results suggest that sphingolipid metabolism is implicated in maintenance of the Golgi architecture and anterograde membrane flow from the endoplasmic reticulum but not in Golgi dispersal induced by BFA.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 02:05:56