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Titolo:
Synthesis of plaunotol derivatives and their antibacterial activities against Helicobacter pylori
Autore:
Tago, K; Minami, E; Masuda, K; Akiyama, T; Kogen, H;
Indirizzi:
Sankyo Co Ltd, Exploratory Chem Res Labs, Shinagawa Ku, Tokyo 1408710, Japan Sankyo Co Ltd Tokyo Japan 1408710 bs, Shinagawa Ku, Tokyo 1408710, Japan
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY
fascicolo: 7, volume: 9, anno: 2001,
pagine: 1781 - 1791
SICI:
0968-0896(200107)9:7<1781:SOPDAT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SQUALENE SYNTHASE INHIBITOR; CAMPYLOBACTER-PYLORIDIS; SCHIZOPHYLLUM-COMMUNE; STRUCTURE ELUCIDATION; PHEROMONE SYNTHESIS; GASTRITIS; SCHIZOSTATIN; DISEASE; REAGENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Kogen, H Sankyo Co Ltd, Exploratory Chem Res Labs, Shinagawa Ku, 1-2-58 Hiromachi, Tokyo 1408710, Japan Sankyo Co Ltd 1-2-58 Hiromachi Tokyo Japan 1408710 408710, Japan
Citazione:
K. Tago et al., "Synthesis of plaunotol derivatives and their antibacterial activities against Helicobacter pylori", BIO MED CH, 9(7), 2001, pp. 1781-1791

Abstract

Plaunotol, a known antiulcer drug, has antibacterial activities against Helicobacter pylori. Plaunotol thiourea derivatives 2-4 and diol derivatives 6-10 were designed in search For a compound with high amtobacteroa; activities. Thiourea derivatives 2-4 were synthesized regioselectively using our effective synthetic route for plaunotol (1), and diol derivatives 6 10 were also synthesized. Their antibacterial activities against H. pylori are described and we found that the most potent antibacterial agent was Cl-thioureaderivative 2c. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 09:55:24