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Titolo:
ortho-Carboranyl glycosides for the treatment of cancer by boron neutron capture therapy
Autore:
Tietze, LF; Bothe, U; Griesbach, U; Nakaichi, M; Hasegawa, T; Nakamura, H; Yamamoto, Y;
Indirizzi:
Univ Gottingen, Inst Organ Chem, D-37077 Gottingen, Germany Univ Gottingen Gottingen Germany D-37077 hem, D-37077 Gottingen, Germany Yamaguchi Univ, Fac Agr, Yamaguchi 7530841, Japan Yamaguchi Univ Yamaguchi Japan 7530841 Fac Agr, Yamaguchi 7530841, Japan Tohoku Univ, Grad Sch Sci, Dept Chem, Sendai, Miyagi 9808578, Japan TohokuUniv Sendai Miyagi Japan 9808578 em, Sendai, Miyagi 9808578, Japan
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY
fascicolo: 7, volume: 9, anno: 2001,
pagine: 1747 - 1752
SICI:
0968-0896(200107)9:7<1747:OGFTTO>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLIOBLASTOMA-MULTIFORME; PHARMACOKINETICS; BORONOPHENYLALANINE; BIODISTRIBUTION; CHEMISTRY; MELANOMA; TUMORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Tietze, LF Univ Gottingen, Inst Organ Chem, Tammannstr 2, D-37077 Gottingen, Germany Univ Gottingen Tammannstr 2 Gottingen Germany D-37077 Germany
Citazione:
L.F. Tietze et al., "ortho-Carboranyl glycosides for the treatment of cancer by boron neutron capture therapy", BIO MED CH, 9(7), 2001, pp. 1747-1752

Abstract

Distinct biological properties of the ortho-carboranyl (1,2-dicarba-closo-dodecaboranyl) glycosides 1, 2 and 3 were evaluated to estimate the suitability of these compounds for cancer treatment by boron neutron capture therapy. The boron uptake into B16-Melanoma cells was significantly higher by incubating the cells with aqueous solutions of carboranyl glucoside 1 (11.2 ppm after 3 h), lactoside 2 (13.2 ppm after 12 h) and maltoside 3 (20.0 ppm after 24 h) compared with solutions of clinically used p-boronophenylalanine (BPA) 5 (3.1 ppm after 34 h), Carboranyl maltoside 3 was more effective than boron-10 enriched 5 in killing C-6 rat glioma cells by incubating the cells with the compound and subsequent treatment with thermal neutrons. 3 was also administrated iv, in concentrations of 25 mg boron/kg body weight torats bearing brain tumors. After a period of 4 h after administration the concentration of boron in the tumor tissue was 3.0 ppm. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 09:53:59