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Titolo:
Anti-HIV and cytotoxic activities of Ru(II)/Ru(III) polypyridyl complexes containing 2,6-(2 '-benzimidazolyl)-pyridine/chalcone as co-ligand
Autore:
Mishra, L; Sinha, R; Itokawa, H; Bastow, KF; Tachibana, Y; Nakanishi, Y; Kilgore, N; Lee, KH;
Indirizzi:
Banaras Hindu Univ, Dept Chem, Varanasi 221005, Uttar Pradesh, India Banaras Hindu Univ Varanasi Uttar Pradesh India 221005 tar Pradesh, India Univ N Carolina, Sch Pharm, Nat Prod Lab, Chapel Hill, NC 27599 USA Univ NCarolina Chapel Hill NC USA 27599 d Lab, Chapel Hill, NC 27599 USA Panacos Pharmaceut, Gaithersburg, MD 20877 USA Panacos Pharmaceut Gaithersburg MD USA 20877 , Gaithersburg, MD 20877 USA
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY
fascicolo: 7, volume: 9, anno: 2001,
pagine: 1667 - 1671
SICI:
0968-0896(200107)9:7<1667:AACAOR>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIBACTERIAL; BINDING; DNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Mishra, L Banaras Hindu Univ, Dept Chem, Varanasi 221005, Uttar Pradesh, India Banaras Hindu Univ Varanasi Uttar Pradesh India 221005 h, India
Citazione:
L. Mishra et al., "Anti-HIV and cytotoxic activities of Ru(II)/Ru(III) polypyridyl complexes containing 2,6-(2 '-benzimidazolyl)-pyridine/chalcone as co-ligand", BIO MED CH, 9(7), 2001, pp. 1667-1671

Abstract

Ru(II)/Ru(III) polypyridyl complexes containing 2.6-(2'-benzimidazolyl)-pyridine or chalcone as co-ligands were synthesized and characterized proviously (Mishra, L.; Sinha, R. Indian J. Chem., Sec. A 2001, in press. Mishra. L.: Sinha, R. Indian J. Chem., Src. A, 39A, 2000, 1131). Their interaction with aqueous buffered calf thymus DNA was measured. (Novakova, O.; Kasparkova, J., Vrana, O.: van Vliet. P. M., Reedijk. J.; Brabec, V, Biochem. 34, 1995, 12369 and these results prompted additional screening for anti-HIV (human immunodeficiency virus) activity against DNA replication in H9 lymphocytes and cytotoxic activity against eight tumor cell lines. The most active compounds were 17 in the former assay (EC50 < 0.1 <mu>g/mL and TI > 23.1) and 3.8. 10, and 14 in the latter assay, especially selectively against the 1A9 ovarian cancer cell line (IC50 = 4.1, 3.8, 3.6, and 2.5 mug/mL. respectively). (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:59:03