Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Thymidine phosphorylase inhibitors with a homophthalimide skeleton
Autore:
Kita, T; Takahashi, H; Hashimoto, Y;
Indirizzi:
Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130032, Japan Univ Tokyo Tokyo Japan 1130032 r Biosci, Bunkyo Ku, Tokyo 1130032, Japan
Titolo Testata:
BIOLOGICAL & PHARMACEUTICAL BULLETIN
fascicolo: 7, volume: 24, anno: 2001,
pagine: 860 - 862
SICI:
0918-6158(200107)24:7<860:TPIWAH>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLIC IMIDE SKELETON; BIOLOGICAL RESPONSE MODIFIERS; AMINOPEPTIDASE-N INHIBITORS; ANALOGS; POTENT; GROWTH;
Keywords:
homophthalimide; thymidine phosphorylase; inhibitor; platelet-derived endothelial cell growth factor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Hashimoto, Y Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, 1-1-1 Yayoi, Tokyo 1130032, Japan Univ Tokyo 1-1-1 Yayoi Tokyo Japan 1130032 yo 1130032, Japan
Citazione:
T. Kita et al., "Thymidine phosphorylase inhibitors with a homophthalimide skeleton", BIOL PHAR B, 24(7), 2001, pp. 860-862

Abstract

Several N-phenylhomophthalimide derivatives were prepared and their inhibitory activity on thymidine phosphorylase/platelet-derived endothelial cell growth factor (TP/PD-ECGF) was assessed. Among them, 2-(2,6-diethylphenyl)-7-nitro-1,2,3,4-tetrahydroisoquinoline-1,3-dione (9) was found to be a morepotent inhibitor than the classical inhibitor, 5-nitrouracil (1), Lineweaver-Burk plot analysis indicated that 9 shows mixed-type competitive inhibition of TP/PD-ECGF, while 1 is a competitive inhibitor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 23:48:23