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Titolo:
Pinealectomy-associated decrease in ribosomal gene activity in rats
Autore:
Payao, SLM; de Carvalho, CV; da Silva, ER; Lopes, C; Markus, RP; Winter, LMF; Smith, MDC;
Indirizzi:
Fac Med Marilia, Disciplina Genet & Biol Mol, Hemocentro, Sao Paulo, Brazil Fac Med Marilia Sao Paulo Brazil iol Mol, Hemocentro, Sao Paulo, Brazil Unifesp, Escola Paulista Med, Dept Morfol, Disciplina Genet, Sao Paulo, Brazil Unifesp Sao Paulo Brazil pt Morfol, Disciplina Genet, Sao Paulo, Brazil Univ Sao Paulo, Dept Parasitol, Inst Ciencias Biomed, Sao Paulo, Brazil Univ Sao Paulo Sao Paulo Brazil Inst Ciencias Biomed, Sao Paulo, Brazil Univ Sao Paulo, Dept Fisiol Anim, Inst Biociencias, Sao Paulo, Brazil UnivSao Paulo Sao Paulo Brazil im, Inst Biociencias, Sao Paulo, Brazil
Titolo Testata:
BIOGERONTOLOGY
fascicolo: 2, volume: 2, anno: 2001,
pagine: 105 - 108
SICI:
1389-5729(2001)2:2<105:PDIRGA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEOLUS ORGANIZER REGIONS; ALZHEIMERS-DISEASE; MELATONIN; CELLS; GLAND; AGE; RNA; RESTRICTION; HELICASE; NORS;
Keywords:
nucleolus organizer regions (NOR); pineal gland; ribosomal genes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Payao, SLM Fac Med Marilia, Disciplina Genet & Biol Mol, Hemocentro, Sao Paulo, Brazil Fac Med Marilia Sao Paulo Brazil mocentro, Sao Paulo, Brazil
Citazione:
S.L.M. Payao et al., "Pinealectomy-associated decrease in ribosomal gene activity in rats", BIOGERONTOL, 2(2), 2001, pp. 105-108

Abstract

A decrease in ribosomal gene activity is an essential feature of the agingprocess as it was observed in Alzheimer's disease, in elderly Down's patients and in elderly healthy people. It is well known that aging is also associated with a reduction in melatonin synthesis. We studied 24 male Wistar rats cytogenetically, by using Ag-stained NOR (6 three-month-old rats underwent. pinealectomy and were studied after 20 days; 6 control rats of the same age 6 three-month-old rats underwent pinealectomy and were studied after 8 months; 6 control rats of the same age). Our results indicate that the absence of the pineal gland leads to a decrease in NOR activity. Further studies are necessary to determine if pinealectomy in rats could provide an animal model for aging.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 08:19:59