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Titolo:
Ageing and the nervous system: insights from studies on invertebrates
Autore:
Yeoman, MS; Faragher, RGA;
Indirizzi:
Univ Brighton, Sch Pharm & Biomol Sci, Brighton BN2 4GJ, E Sussex, EnglandUniv Brighton Brighton E Sussex England BN2 4GJ N2 4GJ, E Sussex, England
Titolo Testata:
BIOGERONTOLOGY
fascicolo: 2, volume: 2, anno: 2001,
pagine: 85 - 97
SICI:
1389-5729(2001)2:2<85:AATNSI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLLUSK LYMNAEA-STAGNALIS; LONG-TERM POTENTIATION; CAENORHABDITIS-ELEGANS; NEURONAL LOSS; LIFE-SPAN; PEPTIDERGIC NEURONS; CALORIC RESTRICTION; RHESUS-MONKEY; AREA CA1; APLYSIA;
Keywords:
ageing; central nervous system; growth factors; invertebrate; neurone loss; synaptic efficacy;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Yeoman, MS Univ Brighton, Sch Pharm & Biomol Sci, Cockcroft Bldg, BrightonBN2 4GJ, ESussex, England Univ Brighton Cockcroft Bldg Brighton E Sussex England BN2 4GJ
Citazione:
M.S. Yeoman e R.G.A. Faragher, "Ageing and the nervous system: insights from studies on invertebrates", BIOGERONTOL, 2(2), 2001, pp. 85-97

Abstract

Ageing can have profound effects on the post-mitotic organ of behaviour, the brain. As yet the precise causes of these deleterious effects are unknown. However, clear insights into the putative mechanisms and consequences ofageing in the CNS have been achieved through the use of invertebrate models. It is now clear that ageing alters the endogenous properties of neurones, their morphology, the efficacy of the connections that the neurones make with their targets and may even lead to neurone loss. While the precise mechanisms underlying these changes are presently unclear clues from post-mitotic organisms such as C. elegans have provided putative targets which are currently being investigated. It is clear to date that the age-induced changes in CNS function observed in invertebrates are conserved in mammalian species and that further work on invertebrates may provide informative insights in to the mechanisms of neuronal ageing.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:38:00