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Titolo:
Colchicine inhibits taurodeoxycholate transport in pericentral but not in periportal hepatocytes
Autore:
Baumgartner, U; Baier, P; Schoffel, U; Farthmann, EH;
Indirizzi:
Univ Freiburg, Dept Surg, D-79106 Freiburg, Germany Univ Freiburg Freiburg Germany D-79106 t Surg, D-79106 Freiburg, Germany
Titolo Testata:
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
fascicolo: 3, volume: 1539, anno: 2001,
pagine: 218 - 224
SICI:
0167-4889(20010620)1539:3<218:CITTIP>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
BILE-ACID TRANSPORT; RAT-LIVER; INTRAHEPATIC CHOLESTASIS; TAUROCHOLATE TRANSPORT; MICROTUBULAR SYSTEM; VESICULAR TRANSPORT; BILIARY-EXCRETION; EXPORT PUMP; SECRETION; SALTS;
Keywords:
bile acid transport; liver heterogeneity; liver perfusion; microtubule-dependent bile acid transport; colchicine-sensitive bile acid transport;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Baumgartner, U Univ Freiburg, Dept Surg, Hugstetter Str 55, D-79106 Freiburg, Germany Univ Freiburg Hugstetter Str 55 Freiburg Germany D-79106 y
Citazione:
U. Baumgartner et al., "Colchicine inhibits taurodeoxycholate transport in pericentral but not in periportal hepatocytes", BBA-MOL CEL, 1539(3), 2001, pp. 218-224

Abstract

Indirect evidence for a microtubule-dependent vesicular hepatocellular transport of bile acids has accumulated. Since inhibition of this transport bycolchicine can be achieved only at high but not at low bile acid infusion rates we were wondering whether this transport pathway shows a hepatic zonation or not. To answer this question we perfused isolated rat livers antegradely or retrogradely, respectively, with unlabeled and labeled taurocholate or taurodeoxycholate. Inhibition of microtubule-dependent bile acid transport was aimed at co-infusion of colchicine. Periportal cells eliminated the likewise hydrophobic taurodeoxycholate as fast as the more hydrophilic taurocholate. In contrast, pericentral cells excreted taurodeoxycholate much slower than taurocholate, Colchicine did not change the biliary taurocholate excretion profile in periportal and pericentral cells. However, colchicine reduced significantly taurodeoxycholate excretion in pericentral but not in periportal cells. It is concluded that a microtubule-dependent vesicular, colchicine-sensitive transport pathway seems to be involved in the translocation of taurodeoxycholate in pericentral but not in periportal cells. Since such a vesicular bile acid transport is regarded to be much slower thantranscellular transport by diffusion, this observation may explain the much slower excretion of hydrophobic bile acids like taurodeoxycholate in pericentral than in periportal cells under physiological conditions. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 16:57:39