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Titolo:
mRNA sequence of the Xenopus laevis paxillin gene and its expression
Autore:
Ogawa, M; Hiraoka, Y; Taniguchi, K; Sakai, Y; Aiso, S;
Indirizzi:
Keio Univ, Sch Med, Dept Immunol, Shinjuku Ku, Tokyo 1608582, Japan Keio Univ Tokyo Japan 1608582 Immunol, Shinjuku Ku, Tokyo 1608582, Japan
Titolo Testata:
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
fascicolo: 3, volume: 1519, anno: 2001,
pagine: 235 - 240
SICI:
0167-4781(20010628)1519:3<235:MSOTXL>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOCAL ADHESION KINASE; TYROSINE PHOSPHORYLATION; EXTRACELLULAR-MATRIX; SIGNAL-TRANSDUCTION; BINDING-PROTEIN; CELL-ADHESION; IDENTIFICATION; CLONING; DOMAIN; CDNA;
Keywords:
LIM motif; nuclear export signal; nuclear translocation; paxillin; Xenopus laevis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Ogawa, M Keio Univ, Sch Med, Dept Immunol, Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan Keio Univ 35 Shinanomachi Tokyo Japan 1608582 kyo 1608582, Japan
Citazione:
M. Ogawa et al., "mRNA sequence of the Xenopus laevis paxillin gene and its expression", BBA-GENE ST, 1519(3), 2001, pp. 235-240

Abstract

Paxillin is a cytoskeletal protein found in structures of focal adhesions where cells adhere to the extracellular matrix. We isolated paxillin cDNA from the Xenopus laevis ovary. The cDNA sequence encodes a protein of 539 amino acids with four LIM and five LD motifs. 80% of the amino acids of frog paxillin are shared by human and chicken paxillins. Northern analysis showed that the frog gene is expressed in the spleen, kidney, testis and ovary. Immunocytochemistry showed that paxillin protein is accumulated in the nucleus as well as in the periphery of the cytoplasm of the A6 cell. This intriguing result shows that paxillin, which has been characterized as a cytoskeletal protein, is capable of translocating to the nucleus. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 05:43:21