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Titolo:
Hormonal treatment of endometrial cancer: past, present and future
Autore:
Podczaski, E; Mortel, R;
Indirizzi:
Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Div Gynecol Oncol, Hershey, PA 17033 USA Penn State Univ Hershey PA USA 17033 Gynecol Oncol, Hershey, PA 17033 USA Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Dept Obstet & Gynecol, Hershey, PA 17033 USA Penn State Univ Hershey PA USA 17033 tet & Gynecol, Hershey, PA 17033 USA Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Ctr Canc, Hershey, PA17033 USA Penn State Univ Hershey PA USA 17033 Med, Ctr Canc, Hershey, PA17033 USA
Titolo Testata:
BEST PRACTICE & RESEARCH IN CLINICAL OBSTETRICS & GYNAECOLOGY
fascicolo: 3, volume: 15, anno: 2001,
pagine: 469 - 489
SICI:
1521-6934(200106)15:3<469:HTOECP>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN ESTROGEN-RECEPTOR; GYNECOLOGIC-ONCOLOGY-GROUP; SEX STEROID-RECEPTORS; MEDROXYPROGESTERONE ACETATE; MEGESTROL-ACETATE; BREAST-CANCER; PROGESTERONE RECEPTORS; PHASE-II; NUCLEAR RECEPTORS; RANDOMIZED TRIAL;
Keywords:
endometrial cancer; oestrogen receptor; progesterone receptor; progestins; tamoxifen;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
90
Recensione:
Indirizzi per estratti:
Indirizzo: Podczaski, E Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Div Gynecol Oncol, 500 Univ Dr, Hershey, PA 17033 USA Penn State Univ 500 Univ Dr Hershey PA USA 17033 PA 17033 USA
Citazione:
E. Podczaski e R. Mortel, "Hormonal treatment of endometrial cancer: past, present and future", BEST P R CL, 15(3), 2001, pp. 469-489

Abstract

The concept that hormonal therapy may be useful in the treatment of endometrial cancer antedated the pharmaceutical availability of progestational compounds. By 1959, initial studies demonstrated the ability of progestins toreverse endometrial hyperplasias. Thereafter, progestins and other hormonal agents have been used in various roles as treatment for endometrial cancers. This chapter reviews the use of hormonal agents for the treatment of primary and metastatic/recurrent endometrial cancer, as well as such treatment in an adjuvant setting. Major problems in enhancing the efficacy of endocrine therapy of cancers arising from hormonally responsive tissues are alsoconsidered. The regulations of steroid-hormone receptor expression in endometrial and breast cancers continues to be an active area of research interest.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:57:27