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Titolo:
Concentration of granulocyte elastase in seminal plasma is not associated with sperm motility
Autore:
Maegawa, M; Kamada, M; Irahara, M; Yamamoto, S; Yamano, S; Ohmoto, Y; Gima, H; Thaler, CJ; Aono, T;
Indirizzi:
Univ Tokushima, Sch Med, Dept Obstet & Gynecol, Tokushima 7708503, Japan Univ Tokushima Tokushima Japan 7708503 Gynecol, Tokushima 7708503, Japan Otsuka Pharmaceut Co Ltd, Cellular Technol Inst, Tokushima 77101, Japan Otsuka Pharmaceut Co Ltd Tokushima Japan 77101 t, Tokushima 77101, Japan Gima Clin, Okinawa, Japan Gima Clin Okinawa JapanGima Clin, Okinawa, Japan Univ Munich, Klinikum Grosshadern, Klin & Poliklin Frauenheilkunde & Geburtshilfe, D-8000 Munich, Germany Univ Munich Munich Germany D-8000 & Geburtshilfe, D-8000 Munich, Germany
Titolo Testata:
ARCHIVES OF ANDROLOGY
fascicolo: 1, volume: 47, anno: 2001,
pagine: 31 - 36
SICI:
0148-5016(200107/08)47:1<31:COGEIS>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEUKOCYTE-PROTEASE INHIBITOR; MALE GENITAL-TRACT; SEMEN QUALITY; LEUKOCYTOSPERMIA; INFLAMMATION;
Keywords:
granulocyte elastase; secretory leukocyte pretense inhibitor; seminal plasma; sperm motility;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Maegawa, M Univ Tokushima, Sch Med, Dept Obstet & Gynecol, 3-18-15 Kuramoto Cho, Tokushima 7708503, Japan Univ Tokushima 3-18-15 Kuramoto Cho Tokushima Japan 7708503 an
Citazione:
M. Maegawa et al., "Concentration of granulocyte elastase in seminal plasma is not associated with sperm motility", ARCH ANDROL, 47(1), 2001, pp. 31-36

Abstract

Although elastase could affect sperm motility in vitro, secretory leukocytes protease inhibitor (SLPI) prevents sperm from being attacked by elastase. The authors investigated the correlations of elastase level with sperm motility and SLPI level in vivo. Semen samples (n = 116) were collected and centrifuged after semen analysis. Elastase and SLPI levels were determined by an enzyme immunosorbent assay. Samples were classified by elastase levelsinto low (<250 ng/mL), moderate (250-1,000 ng/mL), and high elastase groups (<greater than or equal to>1,000 ng/mL). Elastase levels (range, 2.8-23,974.4 ng/mL) were not associated with sperm motility. The median SLPI level in the high elastase group was 15,900 ng/mL (range, 2,860-46,900 ng/mL). However, there was no significant correlation between elastase and SLPI levels in seminal plasma. Since SLPI forms a 1:1 complex with elastase, these results suggest that seminal plasma has a sufficient amount of SLPI to protect spermatozoa from elastase.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 20:12:22