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Titolo:
Alkaloid biosynthesis in plants: Biochemistry, cell biology, molecular regulation, and metabolic engineering applications
Autore:
Facchini, PJ;
Indirizzi:
Univ Calgary, Dept Biol Sci, Calgary, AB T2N 1N4, Canada Univ Calgary Calgary AB Canada T2N 1N4 l Sci, Calgary, AB T2N 1N4, Canada
Titolo Testata:
ANNUAL REVIEW OF PLANT PHYSIOLOGY AND PLANT MOLECULAR BIOLOGY
, volume: 52, anno: 2001,
pagine: 29 - 66
SICI:
1040-2519(2001)52:<29:ABIPBC>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADENOSYL-L-METHIONINE; BERBERINE BRIDGE ENZYME; TRYPTOPHAN DECARBOXYLASE GENE; TRANSGENIC TOBACCO PLANTS; 2 TROPINONE REDUCTASES; HAIRY ROOT CULTURES; HYOSCYAMINE 6-BETA-HYDROXYLASE GENE; PUTRESCINE N-METHYLTRANSFERASE; ESCHSCHOLZIA-CALIFORNICA CHAM.; ELICITOR-INDUCIBLE EXPRESSION;
Keywords:
metabolic engineering; gene regulation; secondary metabolism; signal transduction; subcellular compartmentation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
181
Recensione:
Indirizzi per estratti:
Indirizzo: Facchini, PJ Univ Calgary, Dept Biol Sci, 2500 Univ Dr 1 NW, Calgary, AB T2N 1N4, Canada Univ Calgary 2500 Univ Dr 1 NW Calgary AB Canada T2N 1N4 nada
Citazione:
P.J. Facchini, "Alkaloid biosynthesis in plants: Biochemistry, cell biology, molecular regulation, and metabolic engineering applications", ANN R PLANT, 52, 2001, pp. 29-66

Abstract

Recent advances in the cell, developmental, and molecular biology of alkaloid biosynthesis have heightened our appreciation for the complexity and importance of plant secondary pathways. Several biosynthetic genes involved in the formation of tropane, benzylisoquinoline, and terpenoid indole alkaloids have now been isolated. The early events of signal perception, the pathways of signal transduction, and the function of gene promoters have been studied in relation to the regulation of alkaloid metabolism. Enzymes involved in alkaloid biosynthesis are associated with diverse subcellular compartments including the cytosol, vacuole, tonoplast membrane, endoplasmic reticulum, chloroplast stroma, thylakoid membranes, and perhaps unique "biosynthetic" or transport vesicles. Localization studies have shown that sequential alkaloid biosynthetic enzymes can also occur in distinct cell types, suggesting the intercellular transport of pathway intermediates. Isolated geneshave also been used to genetically alter the accumulation of specific alkaloids and other plant secondary metabolites. Metabolic modifications include increased indole alkaloid levels, altered tropane alkaloid accumulation, elevated serotonin synthesis, reduced indole glucosinolate production, redirected shikimate metabolism, and increased cell wall-bound tyramine formation. This review discusses the biochemistry, cell biology, molecular regulation, and metabolic engineering of alkaloid biosynthesis in plants.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 02:12:29