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Titolo:
The effects of alpha-human atrial natriuretic peptide and milrinone on pial vessels during blood-brain barrier disruption in rabbits
Autore:
Iida, H; Iida, M; Takenaka, M; Oda, A; Uchida, M; Fujiwara, H; Dohi, S;
Indirizzi:
Gifu Univ, Sch Med, Dept Anesthesiol & Crit Care Med, Gifu 5008705, Japan Gifu Univ Gifu Japan 5008705 hesiol & Crit Care Med, Gifu 5008705, Japan Gifu Univ, Sch Med, Dept Internal Med 2, Gifu 5008705, Japan Gifu Univ Gifu Japan 5008705 d, Dept Internal Med 2, Gifu 5008705, Japan
Titolo Testata:
ANESTHESIA AND ANALGESIA
fascicolo: 1, volume: 93, anno: 2001,
pagine: 177 - 182
SICI:
0003-2999(200107)93:1<177:TEOAAN>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-FAILURE; CARDIOPULMONARY BYPASS; INTRAVENOUS MILRINONE; AMRINONE; PHOSPHODIESTERASE; RESUSCITATION; POLYPEPTIDE; IMPAIRMENT; RELAXATION; INHIBITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Iida, H Gifu Univ, Sch Med, Dept Anesthesiol & Crit Care Med, 40 Tsukasamachi, Gifu 5008705, Japan Gifu Univ 40 Tsukasamachi Gifu Japan 5008705 Gifu 5008705, Japan
Citazione:
H. Iida et al., "The effects of alpha-human atrial natriuretic peptide and milrinone on pial vessels during blood-brain barrier disruption in rabbits", ANESTH ANAL, 93(1), 2001, pp. 177-182

Abstract

The effects of ct-human atrial natriuretic peptide (HANP) and milrinone oncerebral pial vessels, especially during blood-brain barrier (BBB) disruption, are not clear. We studied topical HANP (10(-14), 10(-12), and 10(-10) M) or milrinone (10(-7), 10(-5), and 10(-3) M), and TV HANP (0.1, 0.2, and 1.0 mug.kg(-1.)min(-1)) or milrinone (0.5, 5.0, and 20.0 mug(.)kg(-1.)min(-1)) with or without hyperosmolar BBB disruption, using a rabbit cranial window preparation. At 10-12 and 10-10 M topical HANP produced significant arteriolar (16%, 20%, respectively), but no venular dilation. Topical milrinone (10(-3) M) produced significant arteriolar and venular dilation (21%, 8%,respectively). IV HANP produced no arteriolar or venular changes at any dose except during BBB disruption, when it caused a significant arteriolar (16%, 16%, and 17%, respectively), but no venular dilation. In contrast, IV milrinone caused small but significant arteriolar and venular dilation without BBB disruption (arterioles, 6%, 7% and 8%, respectively; venules, 6% at 20.0 mug(.)kg(-1.)min(-1)). During BBB disruption, these responses to milrinone were similar. Although HANP and milrinone each have a direct vasodilator effect on arterioles, their systemic administration at clinical doses could induce different effects. BBB disruptive conditions could increase the response of pial vessels to systemically administered HANP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 15:36:01