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Titolo:
Strain dependence of airway hyperresponsiveness reflects differences in eosinophil localization in the lung
Autore:
Takeda, K; Haczku, A; Lee, JJ; Irvin, CG; Gelfand, EW;
Indirizzi:
Natl Jewish Med & Res Ctr, Dept Pediat, Div Cell Biol, Denver, CO 80206 USA Natl Jewish Med & Res Ctr Denver CO USA 80206 Biol, Denver, CO 80206 USA Natl Jewish Med & Res Ctr, Dept Med, Denver, CO 80206 USA Natl Jewish Med & Res Ctr Denver CO USA 80206 t Med, Denver, CO 80206 USA Mayo Clin Scottsdale, Scottsdale, AZ 85259 USA Mayo Clin Scottsdale Scottsdale AZ USA 85259 le, Scottsdale, AZ 85259 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
fascicolo: 2, volume: 281, anno: 2001,
pagine: L394 - L402
SICI:
1040-0605(200108)281:2<L394:SDOAHR>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALLERGIC INFLAMMATION; PASSIVE TRANSFER; MURINE MODEL; MICE; RESPONSIVENESS; ANTIGEN; MECHANICS; EOTAXIN; MOUSE; HYPERREACTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Gelfand, EW 1400 Jackson St, Denver, CO 80206 USA 1400 Jackson St Denver CO USA 80206 St, Denver, CO 80206 USA
Citazione:
K. Takeda et al., "Strain dependence of airway hyperresponsiveness reflects differences in eosinophil localization in the lung", AM J P-LUNG, 281(2), 2001, pp. L394-L402

Abstract

Different strains of mice exhibit different degrees of airway hyperresponsiveness after sensitization to and airway challenge with ovalbumin. Antibody responses in BALB/c mice far exceeded those in C57BL/6 mice; in contrast,although responsiveness to methacholine was much higher in the BALB/c mice, the number of eosinophils in the bronchoalveolar lavage fluid was higher in C57BL/6 animals. Sensitized and challenged BALB/c mice developed increases in lung resistance and decreases in dynamic compliance after methacholine or 5-hydroxytryptamine inhalation. C57BL/6 mice only exhibited significant levels of responsiveness when dynamic compliance was monitored in response to inhaled 5-hydroxytryptamine. Eosinophils accumulated in the peribronchial and peripheral lung tissue in BALB/c mice but were distributed diffusely in the peripheral lung tissue of C57BL/6 mice. Thus, in addition to differences in antibody responses and cholinergic agonist reactivity, differences in the responses of large and small airways may reflect the selective distribution of eosinophils in lung tissue.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 07:59:33