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Titolo:
Reduced expression of plakoglobin correlates with adverse outcome in patients with neuroblastoma
Autore:
Amitay, R; Nass, D; Meitar, D; Goldberg, I; Davidson, B; Trakhtenbrot, L; Brok-Simoni, F; Ben-Zeev, A; Rechavi, G; Kaufmann, Y;
Indirizzi:
Chaim Sheba Med Ctr, Inst Hematol, IL-52621 Tel Hashomer, Israel Chaim Sheba Med Ctr Tel Hashomer Israel IL-52621 21 Tel Hashomer, Israel Chaim Sheba Med Ctr, Dept Pathol, IL-52621 Tel Hashomer, Israel Chaim Sheba Med Ctr Tel Hashomer Israel IL-52621 21 Tel Hashomer, Israel Chaim Sheba Med Ctr, Inst Pediat Oncol, IL-52621 Tel Hashomer, Israel Chaim Sheba Med Ctr Tel Hashomer Israel IL-52621 21 Tel Hashomer, Israel Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 ch Med, IL-69978 Tel Aviv, Israel Weizmann Inst Sci, Dept Mol Cell Biol, IL-76100 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-76100 Biol, IL-76100 Rehovot, Israel
Titolo Testata:
AMERICAN JOURNAL OF PATHOLOGY
fascicolo: 1, volume: 159, anno: 2001,
pagine: 43 - 49
SICI:
0002-9440(200107)159:1<43:REOPCW>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-CATENIN; N-CADHERIN; CELL-ADHESION; ALPHA-CATENIN; TRANSCRIPTIONAL ACTIVATION; PROTEIN INTERACTIONS; CANCER; CARCINOMAS; MOLECULES; BREAST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Kaufmann, Y Chaim Sheba Med Ctr, Inst Hematol, IL-52621 Tel Hashomer, Israel Chaim Sheba Med Ctr Tel Hashomer Israel IL-52621 mer, Israel
Citazione:
R. Amitay et al., "Reduced expression of plakoglobin correlates with adverse outcome in patients with neuroblastoma", AM J PATH, 159(1), 2001, pp. 43-49

Abstract

Plakoglobin and its homologue beta -catenin are cytoplasmic proteins that mediate adhesive functions by interacting with cadherin receptors and signaling activities by interacting with transcription factors. It has been suggested that plakoglobin can suppress tumorigenicity whereas beta -catenin can act as an oncogene. We investigated the correlation between the expression pattern of N-cadherin, beta -catenin, and plakoglobin and tumor behavior in primary tumors of 20 neuroblastoma patients of all stages and in 11 human neuroblastoma cell lines. N-cadherin and beta -catenin were detected in 9of 11 and 11 of 11 cell lines, respectively, whereas plakoglobin was undetectable or severely reduced in 6 of 11 cell lines. Tumor cells from 16 of 20 patients expressed N-cadherin and 20 of 20 patients expressed beta -catenin at levels similar to those of normal ganglion cells. Plakoglobin was undetectable in 9 of 20 tumors. Plakoglobin deficiency in the primary tumors was significantly associated with adverse clinical outcome. Five of the patients with plakoglobin-negative tumors died whereas four patients are alive without evident disease. In contrast, all patients with plakoglobin-positive tumors are alive; 2 of 11 are alive with the disease and 9 of 11 are alive without evident disease. These results suggest that down-regulation of plakoglobin may be of prognostic value for neuroblastoma patients as predictor of poor outcome.

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Documento generato il 01/12/20 alle ore 01:18:04