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Titolo:
Molecular approaches to cerebral laterality: Development and neurodegeneration
Autore:
Geschwind, DH; Miller, BL;
Indirizzi:
Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 4, volume: 101, anno: 2001,
pagine: 370 - 381
SICI:
0148-7299(20010715)101:4<370:MATCLD>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEFT-RIGHT ASYMMETRY; FRONTOTEMPORAL DEMENTIA; TRANSCRIPTION FACTOR; REGIONAL IDENTITY; PLANUM-TEMPORALE; NERVOUS-SYSTEM; HOMEOBOX GENE; NEURAL PLATE; HUMAN BRAIN; CORTEX;
Keywords:
handedness; left-right axis; asymmetry; language;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
121
Recensione:
Indirizzi per estratti:
Indirizzo: Geschwind, DH Univ Calif Los Angeles, Dept Neurol, 710 Westwood Plaza, LosAngeles, CA 90095 USA Univ Calif Los Angeles 710 Westwood Plaza Los Angeles CA USA 90095
Citazione:
D.H. Geschwind e B.L. Miller, "Molecular approaches to cerebral laterality: Development and neurodegeneration", AM J MED G, 101(4), 2001, pp. 370-381

Abstract

Little is understood about the genetic or epigenetic mechanisms that underlie brain asymmetry. Because higher cognitive functions such as language, constructional and spatial abilities, and attention are organized along the left/right axis, understanding the underpinnings of this process has significant implications for both developmental biology and cognitive neuroscience. However, scientists have begun to explore, in only the most preliminary manner, the influences of subtle biologically inherited brain asymmetries on human behavior and disease. Because brain asymmetry develops prenatally, the recognition of asymmetry in neurodegeneration implies a possible relationship between the development of cerebral laterality and regional vulnerability in neurodegenerative diseases. This suggests that the study of cerebral asymmetry and laterality is likely to be relevant to a number of degenerative conditions that were previously considered to be only diseases of aging. In this article, I will outline our perspective and some of the approaches that my laboratory has begun to take to characterize the molecular basis of cerebral asymmetry. Most of these data are preliminary and the models presented are highly speculative, reflecting the primitive stage of work defining the molecular basis of cerebral asymmetry. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:44:30