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Titolo:
Lack of association of the (AAAT)(6) allele of the GXAlu tetranucleotide repeat in intron 27b of the NF1 gene with autism
Autore:
Plank, SM; Copeland-Yates, SA; Sossey-Alaoui, K; Bell, JM; Schroer, RJ; Skinner, C; Michaelis, RC;
Indirizzi:
Greenwood Genet Ctr, JC Self Res Inst, Greenwood, SC 29646 USA Greenwood Genet Ctr Greenwood SC USA 29646 Inst, Greenwood, SC 29646 USA Presbyterian Coll, Clinton, SC USA Presbyterian Coll Clinton SC USAPresbyterian Coll, Clinton, SC USA Clemson Univ, Clemson, SC USA Clemson Univ Clemson SC USAClemson Univ, Clemson, SC USA
Titolo Testata:
AMERICAN JOURNAL OF MEDICAL GENETICS
fascicolo: 5, volume: 105, anno: 2001,
pagine: 404 - 405
SICI:
0148-7299(20010708)105:5<404:LOAOT(>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROFIBROMATOSIS TYPE-1 GENE;
Keywords:
autistic disorder; association studies; neurofibromatosis 1 gene;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Michaelis, RC Greenwood Genet Ctr, JC Self Res Inst, 1 Gregor Mendel Circle, Greenwood, SC 29646 USA Greenwood Genet Ctr 1 Gregor Mendel Circle Greenwood SC USA 29646
Citazione:
S.M. Plank et al., "Lack of association of the (AAAT)(6) allele of the GXAlu tetranucleotide repeat in intron 27b of the NF1 gene with autism", AM J MED G, 105(5), 2001, pp. 404-405

Abstract

A novel allele of the GXAlu tetranucleotide repeat in intron 27b of the neurofibromatosis 1 (NF1) gene has recently been reported to be present in 4.7% of autistic patients but not in controls. We have found the novel GXAlu allele absent in 204 patients from the South Carolina Autism Project and 200 controls. The autism population studied includes a significant number of patients with hypotonia, stereotyped behaviors, or postural, gait, and motor abnormalities similar to those seen in the patients previously reported to possess the novel GXAlu allele, This suggests that the novel (AAAT)(6) GXAlu allele is not associated with autism. (C) 2001 Wiley-Liss. Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 16:11:23