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Titolo:
Long-term endothelin receptor blockade improves cardiovascular function indiabetes
Autore:
Verma, S; Arikawa, E; McNeill, JH;
Indirizzi:
Univ British Columbia, Fac Pharmaceut Sci, Div Pharmacol & Toxicol, Vancouver, BC V6T 1Z3, Canada Univ British Columbia Vancouver BC Canada V6T 1Z3 ver, BC V6T 1Z3, Canada
Titolo Testata:
AMERICAN JOURNAL OF HYPERTENSION
fascicolo: 7, volume: 14, anno: 2001,
parte:, 1
pagine: 679 - 687
SICI:
0895-7061(200107)14:7<679:LERBIC>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR SMOOTH-MUSCLE; VENTRICULAR MYOCYTES; HEART-FAILURE; CARDIAC-FUNCTION; GENE-EXPRESSION; RAT; INHIBITION; ANTAGONIST; RESPONSES; BOSENTAN;
Keywords:
endothelin-1; streptozotocin-induced diabetes; endothelin receptor blocker; bosentan; cardiac function; vascular reactivity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: McNeill, JH Univ British Columbia, Fac Pharmaceut Sci, Div Pharmacol & Toxicol, Vancouver, BC V6T 1Z3, Canada Univ British Columbia Vancouver BC Canada V6T 1Z3 1Z3, Canada
Citazione:
S. Verma et al., "Long-term endothelin receptor blockade improves cardiovascular function indiabetes", AM J HYPERT, 14(7), 2001, pp. 679-687

Abstract

To evaluate the potential contribution of endothelin-1 (ET-1) toward the cardiovascular complications of diabetes, the present study examined the effects of chronic ET receptor blockade with bosentan on heart function and vascular reactivity in streptozotocin (STZ)-induced diabetic rats. Wistar rats were divided into four groups: control, control bosentan-treated, diabetic, and diabetic bosentan-treated. After chronic bosentan treatment, cardiacfunction and vascular reactivity were assessed. Exvivo wet-king heart function was determined in terms of rate of contraction (+dP/dt), rate of relaxation (-dP/dt), and left ventricular developed pressure (LVDP). Contractileresponses to ET-1 were determined in isolated superior mesenteric arteries, In addition, ET-1-like immunoreactivity was determined in ventricular andvascular tissues by immunohistochemistry. Cardiac function was depressed in the untreated-diabetic group. Bosentan treatment improved working heart function; hearts from the diabetic bosentan-treated group exhibited improvedLVDP and -dP/dt. The contractile responses of mesenteric arteries to ET-1 were exaggerated in the untreated-diabetic group. Long-term bosentan treatment normalized these responses. Immunohistochemical analyses revealed increased ET-1-like immunoreactivity in ventricular and vascular tissues from untreated diabetic rats. These data show the beneficial effects of ET, receptor blockade on cardiovascular function in STZ-diabetic rats. An altered ET-1 system may contribute toward the pathogenesis of cardiovascular dysfunction in diabetes. (C) 2001 American Journal of Hypertension, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 13:55:35