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Titolo:
Does leptin cause functional peripheral sympatholysis?
Autore:
Jalali, A; Morgan, DA; Sivitz, WI; Correia, MLG; Mark, AL; Haynes, WG;
Indirizzi:
Univ Iowa, Coll Med, Dept Internal Med, Hypertens Genet Specialised Ctr Res, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 ialised Ctr Res, Iowa City, IA 52242 USA Vet Affairs Med Ctr, Iowa City, IA 52242 USA Vet Affairs Med Ctr Iowa City IA USA 52242 d Ctr, Iowa City, IA 52242 USA
Titolo Testata:
AMERICAN JOURNAL OF HYPERTENSION
fascicolo: 7, volume: 14, anno: 2001,
parte:, 1
pagine: 615 - 618
SICI:
0895-7061(200107)14:7<615:DLCFPS>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-PRESSURE; OBESE GENE; OB/OB MICE; NERVE;
Keywords:
leptin; blood flow; sympathetic nerve; nitric oxide; nerve stimulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Haynes, WG Univ Iowa, Coll Med, Dept Internal Med, Hypertens Genet Specialised Ctr Res, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 Res, Iowa City, IA 52242 USA
Citazione:
A. Jalali et al., "Does leptin cause functional peripheral sympatholysis?", AM J HYPERT, 14(7), 2001, pp. 615-618

Abstract

Leptin is a protein produced by adipocytes. Leptin is known to markedly and rapidly increase sympathetic nerve activity to the kidney and hindlimb ofexperimental animals. Recent studies suggest that leptin may stimulate endothelial production of nitric oxide, which could oppose sympathetically induced vasoconstriction. We tested the hypothesis that such actions of leptinmay produce peripheral functional sympatholysis. In Sprague-Dawley rats, we intermittently stimulated the abdominal sympathetic trunk and measured renal and hindlimb blood flows before and after 3 h of infusion of leptin (1000 mug/kg, n = 7) or vehicle (n = 7). Leptin did not change arterial pressure, heart rate, or renal or hindlimb conductance over the course of 3 h. Inaddition, leptin did not significantly alter sympathetically mediated vasomotor responses to electrical stimulation, as compared with vehicle. Thus, we conclude that leptin does not change regional blood flows, and that leptin also does not appear to have vascular or neural actions to cause peripheral functional sympatholysis. (C) 2001 American Journal of Hypertension, Ltd.

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Documento generato il 22/01/20 alle ore 09:24:12