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Titolo:
Lipid transfer proteins and 2S albumins as allergens
Autore:
Pastorello, EA; Pompei, C; Pravettoni, V; Brenna, O; Farioli, L; Trambaioli, C; Conti, A;
Indirizzi:
Osped Maggiore, IRCCS, Div Gen Med 3, Allergy Ctr, Milan, Italy Osped Maggiore Milan Italy CS, Div Gen Med 3, Allergy Ctr, Milan, Italy Univ Milan, Dept Food Sci & Microbiol, Milan, Italy Univ Milan Milan Italy v Milan, Dept Food Sci & Microbiol, Milan, Italy UOOML, Milan, Italy UOOML Milan ItalyUOOML, Milan, Italy Natl Res Council, Turin, Italy Natl Res Council Turin ItalyNatl Res Council, Turin, Italy
Titolo Testata:
ALLERGY
, volume: 56, anno: 2001, supplemento:, 67
pagine: 45 - 47
SICI:
0105-4538(2001)56:<45:LTPA2A>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEACH PRUNUS-PERSICA; AMINO-ACID-SEQUENCE; MAJOR ALLERGEN; BRAZIL-NUT; STORAGE PROTEINS; RICH PROTEIN; SEED; CLONING; IDENTIFICATION; EXPRESSION;
Keywords:
food allergens; lipid transfer proteins; 2S albumins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Pastorello, EA Div Gen Med 3, Padiglione Granelli,Via Francesco Sforza 35,I-20122 Milan,Italy Div Gen Med 3 Padiglione Granelli,Via Francesco Sforza35 Milan Italy I-20122
Citazione:
E.A. Pastorello et al., "Lipid transfer proteins and 2S albumins as allergens", ALLERGY, 56, 2001, pp. 45-47

Abstract

Plant lipid transfer proteins, a widespread family of proteins, have been recently identified as important food allergens. Their common structural features, such as eight conserved cysteines forming disulfide bridges, basic isoelectric point and high similarity in amino acid sequence, are the basisof allergic clinical crossreactivity. This has been demonstrated for the LTP allergens of the Prunoideae subfamily, whose similarity is about 95% as demonstrated for the purified allergens of peach, apricot, plum and apple. A relevant aspect is the existence of sequence homology of LTPs of botanically unrelated foods, as demonstrated for LTPs of maize and peach. A class of food allergens of well recognized clinical importance is that of seed storage 2S albumins. They have been identified in the most diffused edible seeds and nuts, such as mustard, sesame, Brazil nut, walnut and peanut. In particular, a strong correlation between IgE-binding to these proteins and food-induced anaphylaxis has been demonstrated for Brazil nut and sesame seeds.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:50:06