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Titolo:
Arrest of chronic acid suppressant drug use after successful Helicobacter pylori eradication in patients with peptic ulcer disease: a six-month follow-up study
Autore:
Hurenkamp, GJB; Grundmeijer, HGLM; Van der Ende, A; Tytgat, GNJ; Assendelft, WJJ; Van der Hulst, RWM;
Indirizzi:
Univ Amsterdam, Acad Med Ctr, Dept Gen Practice, Div Publ Hlth, NL-1105 AZAmsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ AZAmsterdam, Netherlands Univ Amsterdam, Acad Med Ctr, Dept Gastroenterol, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands Univ Amsterdam, Acad Med Ctr, Dept Med Microbiol, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands NL-1105 AZ Z Amsterdam, Netherlands Kennemer Gasthuis, Dept Gastroenterol, Haarlem, Netherlands Kennemer Gasthuis Haarlem Netherlands stroenterol, Haarlem, Netherlands
Titolo Testata:
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
fascicolo: 7, volume: 15, anno: 2001,
pagine: 1047 - 1054
SICI:
0269-2813(200107)15:7<1047:AOCASD>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
DUODENAL-ULCER; HYPERSECRETION; ESOPHAGITIS; MULTICENTER; PREVALENCE; DYSPEPSIA; INFECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Hurenkamp, GJB Univ Amsterdam, Acad Med Ctr, Dept Gen Practice, Div Publ Hlth, Meibergdreef 15, NL-1105 AZ Amsterdam, Netherlands Univ Amsterdam Meibergdreef 15 Amsterdam Netherlands NL-1105 AZ
Citazione:
G.J.B. Hurenkamp et al., "Arrest of chronic acid suppressant drug use after successful Helicobacter pylori eradication in patients with peptic ulcer disease: a six-month follow-up study", ALIM PHARM, 15(7), 2001, pp. 1047-1054

Abstract

Background: It remains controversial whether successful H. pylori eradication leads to relief of dyspepsia and the subsequent arrest or tapering of acid-suppressant drug therapy, or to an aggravation of acid-related dyspepsia requiring more acid-suppressant drug intake. Aim: To evaluate prospectively the effect of H. pylori eradication on the requirement of acid-suppressant drug or antacids and the evolution of dyspeptic symptoms in chronic acid-suppressant drug users with peptic ulcer disease. Materials and methods: The use of acid-suppressant drugs, rescue antacids and predominant symptoms were recorded prospectively during 24 weeks after H. pylori eradication therapy in 75 peptic ulcer disease patients. Results: In 71 patients with complete follow-up, ulcers were healed at follow-up endoscopy and H. pylori was successfully eradicated. After 6 months,93% (66 out of 71) of chronic acid-suppressant drug users had stopped acid-suppressant drug intake. The mean daily acid-suppressant drug dosage per patient decreased from 1.72 at entry to 0.03 units acid-suppressant drug (98%; P < 0.0001) during follow-up. The mean number of antacid tablets/day/patient was 0.26 during follow-up for the relief of mild inter-current dyspeptic symptoms. Medication use was not different in peptic ulcer disease patients with or without gastrooesophageal reflux disease at baseline, The prevalence of gastro-oesophageal reflux disease decreased from 42% before to 35%after H. pylori eradication (N.S.). Conclusion: Successful H. pylori eradication in peptic ulcer disease patients almost completely eliminates the need for acid-suppressant drug regardless of the presence or absence of gastro-oesophageal reflux disease at entry.

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Documento generato il 01/10/20 alle ore 03:31:21