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Titolo:
Molecular cloning of feline interferon-gamma-inducing factor (interleukin-18) and its expression in various tissues
Autore:
Ishizaka, T; Setoguchi, A; Masuda, K; Ohno, K; Tsujimoto, H;
Indirizzi:
Univ Tokyo, Grad Sch Agr & Life Sci, Dept Vet Internal Med, Bunkyo Ku, Tokyo 1138657, Japan Univ Tokyo Tokyo Japan 1138657 rnal Med, Bunkyo Ku, Tokyo 1138657, Japan
Titolo Testata:
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
fascicolo: 3-4, volume: 79, anno: 2001,
pagine: 209 - 218
SICI:
0165-2427(20010530)79:3-4<209:MCOFIF>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; T-CELLS; CRYPTOCOCCUS-NEOFORMANS; PROTECTS MICE; IN-VIVO; IL-12; INFECTION; CYTOTOXICITY; ACTIVATION; CYTOKINE;
Keywords:
cat; cloning; cytokine; interleukin-18;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Ohno, K Univ Tokyo, Grad Sch Agr & Life Sci, Dept Vet Internal Med, BunkyoKu, 1-1-1 Yayoi, Tokyo 1138657, Japan Univ Tokyo 1-1-1 Yayoi Tokyo Japan 1138657 , Tokyo 1138657, Japan
Citazione:
T. Ishizaka et al., "Molecular cloning of feline interferon-gamma-inducing factor (interleukin-18) and its expression in various tissues", VET IMMUNOL, 79(3-4), 2001, pp. 209-218

Abstract

Interleukin-18 (IL-18) is a cytokine with potent interferon-gamma -inducing activity, and plays an important biologic role in the enhancement of the activity of natural killer cells and cytotoxic T-lymphocytes. In this study, feline IL-18 cDNA was cloned and characterized to establish a basis for the prospective cytokine therapy in small animal practice. The nucleotide sequence of feline IL-18 cDNA obtained in this study was 712 bp long and contained its entire open reading frame encoding 192 amino acid residues. The predicted amino acid sequence of feline IL-18 cDNA showed 77.2, 84.8, 60.2 and 62.6% similarity with those of human, dog, rat and mouse counterparts, respectively. The feline IL-18 cDNA included a putative cleavage site of IL-1 beta -converting enzyme (ICE) and IL-1 signature-like sequences identified in human and mouse IL-18 cDNAs. Expression of IL-18 mRNA was detected in various tissues including spleen, liver and cerebrum in the cat. (C) 2001 Published by Elsevier Science B.V.

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Documento generato il 05/12/20 alle ore 01:27:54