Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Nuclear-receptor interactions on DNA-response elements
Autore:
Khorasanizadeh, S; Rastinejad, F;
Indirizzi:
Univ Virginia, Sch Med, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA Univ Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA Univ Virginia, Sch Med, Dept Pharmacol, Charlottesville, VA 22908 USA UnivVirginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA
Titolo Testata:
TRENDS IN BIOCHEMICAL SCIENCES
fascicolo: 6, volume: 26, anno: 2001,
pagine: 384 - 390
SICI:
0968-0004(200106)26:6<384:NIODE>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIGAND-BINDING DOMAINS; RETINOIC ACID RECEPTOR; CRYSTAL-STRUCTURE; ORPHAN RECEPTORS; DIRECT REPEATS; TRANSCRIPTIONAL ACTIVATION; GLUCOCORTICOID RECEPTOR; TRANSACTIVATION DOMAIN; COMPLEX-FORMATION; MONOMER-BINDING;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Khorasanizadeh, S Univ Virginia, Sch Med, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA Univ Virginia Charlottesville VA USA 22908 VA 22908 USA
Citazione:
S. Khorasanizadeh e F. Rastinejad, "Nuclear-receptor interactions on DNA-response elements", TRENDS BIOC, 26(6), 2001, pp. 384-390

Abstract

Nuclear receptors regulate transcription by binding to DNA-response elements using their conserved DNA-binding domains, These response elements contain conserved hexameric sequences that can be arranged in various bipartite configurations, including inverted and direct repeats. A series of structural studies on receptor-DNA binding complexes illustrate the strategies usedby receptors to recognize the symmetry of their binding site as well as its sequence. These structures also indicate how cooperation between receptors enhances their joint affinity and selectivity for correctly configured sites.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 05:30:31