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Titolo:
Novel in vitro assays for assessing the haemorrhagic activity of snake venoms and for demonstration of venom metalloproteinase inhibitors
Autore:
Bee, A; Theakston, RDG; Harrison, RA; Carter, SD;
Indirizzi:
Univ Liverpool, Connect Tissue Res Grp, Fac Vet Med, Liverpool L69 3BX, Merseyside, England Univ Liverpool Liverpool Merseyside England L69 3BX , Merseyside, England Univ Liverpool, Liverpool Sch Trop Med, Alistair Reid Venom Res Unit, Liverpool L3 5QA, Merseyside, England Univ Liverpool Liverpool Merseyside England L3 5QA A, Merseyside, England
Titolo Testata:
TOXICON
fascicolo: 9, volume: 39, anno: 2001,
pagine: 1429 - 1434
SICI:
0041-0101(200109)39:9<1429:NIVAFA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMORRHAGIC METALLOPROTEINASES; TRIMERESURUS-FLAVOVIRIDIS;
Keywords:
venom; gelatinase; in vitro haemorrhagic assay; MP inhibitors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Bee, A Univ Liverpool, Connect Tissue Res Grp, Fac Vet Med, Liverpool L69 3BX, Merseyside, England Univ Liverpool Liverpool Merseyside England L69 3BX yside, England
Citazione:
A. Bee et al., "Novel in vitro assays for assessing the haemorrhagic activity of snake venoms and for demonstration of venom metalloproteinase inhibitors", TOXICON, 39(9), 2001, pp. 1429-1434

Abstract

Standard methods used for assessing the haemorrhagic toxicity of snake venoms and the effectiveness of antivenoms are laborious, expensive and involve the use of large numbers of laboratory animals. This paper examined the feasibility of using a gelatin degradation ELISA for preliminary screening of snake venom metalloproteinases (MPs). Potent gelatinolytic activity was observed in venoms from snakes of the family Viperidae and, as expected, little or no activity was evident in the venoms of snakes that induce neurotoxic pathology (most elapids). A reverse gelatin zymography assay was used ona variety of Venoms to demonstrate a number of inhibitors of MP activity, the first such demonstration of its kind. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 14:44:14