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Titolo:
Vitamin E protects against iron-hexachlorobenzene induced porphyria and formation of 8-hydroxydeoxyguanosine in the liver of C57BL/10ScSn mice
Autore:
Horvath, ME; Faux, SP; Smith, AG; Blazovics, A; van der Looij, M; Feher, J; Cheeseman, KH;
Indirizzi:
Semmelweis Univ, Sch Med, Dept Med 2, H-1088 Budapest, Hungary Semmelweis Univ Budapest Hungary H-1088 Med 2, H-1088 Budapest, Hungary Univ Leicester, MRC, Toxicol Unit, Leicester, Leics, England Univ Leicester Leicester Leics England l Unit, Leicester, Leics, England Natl Inst Oncol, Dept Mol Biol, Budapest, Hungary Natl Inst Oncol Budapest Hungary ncol, Dept Mol Biol, Budapest, Hungary Astra Draco, Dept Clin Res & Dev, Lund, Sweden Astra Draco Lund SwedenAstra Draco, Dept Clin Res & Dev, Lund, Sweden
Titolo Testata:
TOXICOLOGY LETTERS
fascicolo: 1, volume: 122, anno: 2001,
pagine: 97 - 102
SICI:
0378-4274(20010531)122:1<97:VEPAII>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATIC UROPORPHYRINOGEN DECARBOXYLASE; INDUCED LIPID-PEROXIDATION; CHROMATOGRAPHY; OXIDATION; SYNERGISM; PLASMA; INVIVO; SERUM; RATS; DNA;
Keywords:
vitamin E; porphyria; DNA; liver; 8-hydroxyguanosine; hexachlorobenzene;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Horvath, ME Semmelweis Univ, Sch Med, Dept Med 2, Szentkriralyi 46, H-1088Budapest, Hungary Semmelweis Univ Szentkriralyi 46 Budapest Hungary H-1088 gary
Citazione:
M.E. Horvath et al., "Vitamin E protects against iron-hexachlorobenzene induced porphyria and formation of 8-hydroxydeoxyguanosine in the liver of C57BL/10ScSn mice", TOX LETT, 122(1), 2001, pp. 97-102

Abstract

The effect of vitamin E treatment on total porphyrin content, lipid peroxidation (LOOH) and 8-hydroxydeoxyguanosine (8-OHdG) was studied in the livers of C57BL/10ScSn mice following hexachlorobenzene (HCB) and iron treatment. HCB was administered i.p. (totalling 300 mg/kg) twice, with 1 week interval. Three days after the first HCB injection iron-dextran was given i.p. (500 mg Fe per kg). Vitamin E was administered weekly (20 mg/kg) by s.c. injection, Both total hepatic porphyrin and LOOH levels were significantly (P<0.001) increased in the HCB-iron treated group as compared with the control group. Mice treated additionally with vitamin E had significant (P<0.001) lower levels as compared with the HCB-iron group. Similarly, the levels of 8-OHdG were significantly (P<0.001) increased above controls after HCB-iron treatment and this increase was reduced after co-treatment with vitamin E (P<0.02). The data support the hypothesis that the mechanism of hepatic porphyrinogenicity of HCB with iron overload is an oxidative free radical process. (C) 2001 Elsevier Science Ireland Ltd. Ail rights reserved.

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Documento generato il 01/06/20 alle ore 02:30:37